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Peripheral basophilia was present in four cases, providing a clinical clue that the Philadelphia chromosome might be present. Marrow biopsy showed granulocytic hyperplasia and either small megakaryocytes or sheets of megakaryocytes with marked atypia, findings that are more typical of CML than ET. The clinical importance of finding the Philadelphia chromosome in patients who seem to have ET is in assessing prognosis. ET generally follows a chronic, indolent course. However, five of these six patients who had the Philadelphia chromosome underwent clinical transition to the accelerated phase of CML or blastic leukemia in 4\u20137 years.<\/jats:p>","DOI":"10.1002\/ajh.2830270202","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:31:27Z","timestamp":1172057487000},"page":"77-83","source":"Crossref","is-referenced-by-count":61,"title":["Clinical presentation and natural history of patients with essential thrombocythemia and the Philadelphia chromosome"],"prefix":"10.1002","volume":"27","author":[{"given":"D. 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