{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T06:10:02Z","timestamp":1697955002651},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":6675,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1988,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A Bam HI restriction fragment length polymorphism in the interzeta hypervariable region (IZ HVR) of the \u03b6\u2010\u03b1 gene cluster was used for the prenatal diagnosis of a pregnancy at risk for Hb H hydrops fetalis. The parents had \u03b6\u2010\u03b1 thalassemia 1 and non\u2010deletion \u03b1 thalassemia, respectively, and a previous hydrops was missed using the conventional method of gene detection. In this prenatal diagnosis, linkage to IZ HVR was used to exclude non\u2010deletion \u03b1 thalassemia, and the numbers of \u03b6 and \u03b1 genes in the fetus were quantitated to predict the exact genotype. Confirmation was made by analysis of cord blood at delivery.<\/jats:p>","DOI":"10.1002\/ajh.2830270403","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:25:39Z","timestamp":1172057139000},"page":"242-246","source":"Crossref","is-referenced-by-count":0,"title":["Restriction fragment length polymorphism in the interzeta hypervariable region for prenatal diagnosis of non\u2010deletion \u03b1 thalassemia"],"prefix":"10.1002","volume":"27","author":[{"given":"Vivian","family":"Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. K.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. C. K.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. P. 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