{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:52:02Z","timestamp":1770508322371,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":6645,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1988,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chromosome analyses were carried out on bone marrow cells from 43 consecutive patients with primary myelodysplastic syndromes (MDS), classified according to the French\u2010American\u2010British (FAB) cooperative group criteria. The objective was to evaluate the prognostic value of clonal chromosomal abnormalities and of an excess of blasts for early death from acute nonlymphocytic leukemia (ANLL) and\/or bone marrow failure (BMF). Patients were subdivided into two main groups: (1) refractory anemia without an excess of blasts (<jats:italic>RAWEB<\/jats:italic>), grouping patients with refractory anemia (RA) and refractory anemia with ringed sideroblasts (RARS), and (2) refractory anemia with an excess of blasts (<jats:italic>RAEB<\/jats:italic>), grouping patients with refractory anemia with an excess of blasts (RAEB) and refractory anemia with an excess of blasts in transformation (RAEBt). There were 29 patients with RAWEB and 14 with RAEB. The median time of observation was 26 months for RAWEB and 12 months for RAEB. Ten RAWEB patients (34%) and 11 RAEB patients (78%) had clonai chromosomal abnormalities. Among the ten RAWEB patients with clonal abnormalities, one (10%) died from ANLL, while of 19 RAWEB patients with a normal karyotype, two (10%) died from ANLL or BMF. The median survival for patients with RAWEB and an abnormal karyotype was not reached. In contrast, eight of the 11 RAEB patients with clonal chromosomal abnormalities (74%) died from ANLL or BMF. The median survival in this sub\u2010group was 7 months. By using a Cox proportional hazard regression analysis, it was determined that a karyotype abnormality was not a significant predictory of survival once the contribution of the RAWEB\/RAEB variable was taken into account. Being in the RAEB group was associated with a relative risk of 10.6 of dying from ANLL or BMF (\u03b2 = 2.36, standard error (SE) = 0.68,<jats:italic>P<\/jats:italic>= .0001). We conclude that classifying patients according to an excess of blasts will lead to a better prediction of survival than determining karyotype abnormality.<\/jats:p>","DOI":"10.1002\/ajh.2830280104","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:24:23Z","timestamp":1172057063000},"page":"13-20","source":"Crossref","is-referenced-by-count":26,"title":["Prognostic value of clonal chromosomal abnormalities in patients with primary myelodysplastic syndromes"],"prefix":"10.1002","volume":"28","author":[{"given":"Martin","family":"Gyger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Infante\u2010Rivard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"D'Angelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorraine","family":"Forest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Lussier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V41.1.93.93"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(82)90011-5"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V60.4.864.864"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V67.2.415.415"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1182\/blood.V68.6.1242.1242","article-title":"Acute myelomonocytic leukemia with abnormal eosinophils and inv(16) or t(16:16) has a favorable prognosis","volume":"68","author":"Larson RA","year":"1986","journal-title":"Blood"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(84)80005-9"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2141.1982.tb08475.x","article-title":"The French\u2010American\u2010British (FAB) Cooperative Group: Proposals for the classification of the myelodysplastic syndromes","volume":"51","author":"Bennett JM","year":"1982","journal-title":"Br J Haematol"},{"key":"e_1_2_1_9_2","first-page":"909","article-title":"Classification of the myelodysplastic syndromes","volume":"15","author":"Bennett JM","year":"1986","journal-title":"Clin Haematol"},{"key":"e_1_2_1_10_2","first-page":"953","article-title":"Myelodysplastic syndromes: Natural history and features of prognostic importance","volume":"15","author":"Mufti GJ","year":"1986","journal-title":"Clin Haematol"},{"key":"e_1_2_1_11_2","first-page":"140a","article-title":"Clinical significance of the new proposals for the classification of the myelodysplastic syndromes","volume":"60","author":"Varela BL","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830701)52:1<83::AID-CNCR2820520117>3.0.CO;2-9"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1985.tb07329.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1986.tb00853.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2900030108"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life tables (with discussion)","volume":"34","author":"Cox DR","year":"1972","journal-title":"JR Stat SOC B"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1182\/blood.V57.4.712.712","article-title":"Acute nodymphocytic leukemia, preleukemia, and acute myeloproliferative syndrome secondary to treatment of other malignant diseases. Clinical and cytogenetic characteristics and results of in vitro culture of bone marrow and HLA typing","volume":"57","author":"Pedersen\u2010Bjergaard J","year":"1981","journal-title":"Blood"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V58.4.759.759"},{"key":"e_1_2_1_19_2","first-page":"9","article-title":"Interstitial deletion of the long arm of chromosome 5 (5q\u2013) in leukemia and other hematological disorders: Clinical and biological relevance of variable breakpoint patterns","volume":"10","author":"Gyger M","year":"1986","journal-title":"Lmk Res"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000130909"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1182\/blood.V47.5.705.705","article-title":"Chromosomal banding patterns in acute leukemia","volume":"47","author":"Rowley JD","year":"1976","journal-title":"Blood"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21979"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(86)90155-X"},{"key":"e_1_2_1_24_2","first-page":"981","article-title":"Phase 1 clinical trial of 13\u2010cis\u2010retinoic acid in myelodysplastic syndromes","volume":"67","author":"Gold EJ","year":"1983","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197912)44:6<1976::AID-CNCR2820440603>3.0.CO;2-#"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1986.tb07524.x"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1984.tb06081.x"},{"key":"e_1_2_1_28_2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1182\/blood.V69.1.92.92","article-title":"Treatment of preleukemic syndromes with marrow transplantation","volume":"69","author":"Appelbaum FR","year":"1987","journal-title":"Blood"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1984.tb06079.x"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(83)90141-3"},{"key":"e_1_2_1_31_2","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1182\/blood.V67.6.1765.1765","article-title":"Prognostic implications of morphology and karyotype in primary myelodysplastic syndromes","volume":"67","author":"Jacobs RH","year":"1986","journal-title":"Blood"},{"key":"e_1_2_1_32_2","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1182\/blood.V67.6.1721.1721","article-title":"Refined chromosome analysis as an independent prognostic indicator in de novo myelodysplastic syndromes","volume":"67","author":"Yunis JJ","year":"1986","journal-title":"Blood"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1986.tb00855.x"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(82)90023-6"},{"key":"e_1_2_1_35_2","first-page":"813","article-title":"Correlation between chromosomal abnormalities and a scoring system of dysmyelopoiesis in the myelodysplastic syndrome (MDS)","volume":"64","author":"Bynoe AG","year":"1986","journal-title":"Br J Haematol"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1986.tb02231.x"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830280104","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830280104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T23:39:47Z","timestamp":1736811587000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830280104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,5]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,5]]}},"alternative-id":["10.1002\/ajh.2830280104"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830280104","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,5]]}}}