{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T06:10:03Z","timestamp":1698041403076},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":6645,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1988,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Glucose\u20106\u2010phosphate\u2010dehydrogenase deficiency is the most common disease\u2010producing enzyme deficiency in man. This paper describes a new glucose\u20106\u2010phosphate\u2010dehy\u2010drogenase variant discovered during the evaluation of an episode of acute hemolytic anemia in a 62\u2010year\u2010old black male, which was temporally related to the ingestion of Tolbutamide. The hemolysis resolved within 10 days despite continuation of Tolbutamide. The erythrocyte glucose\u20106\u2010phosphate\u2010dehydrogenase activity was significantly decreased, and its electrophoretic mobility was indistinguishable from wild type enzyme, though faster on starch gel with tris, borate, and phosphate buffers. The enzyme had a biphasic pH optimum reduced Km for G\u20106\u2010P and NADP, decreased utilization of deamino\u2010NADP, and reduced Ki for NADPH. Because the kinetic properties of this enzyme were unique, we have designated it as G6PD Central City.<\/jats:p>","DOI":"10.1002\/ajh.2830280114","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:24:23Z","timestamp":1172057063000},"page":"61-62","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of a new glucose\u20106\u2010phosphate dehydrogenase variant: GGPD central city"],"prefix":"10.1002","volume":"28","author":[{"given":"Magdolena","family":"Csepreghy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen","family":"Yeilding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Lilly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelley","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. W.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef T.","family":"Prchal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"561","volume-title":"Hematology","author":"Beutler E","year":"1983"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1983.tb00967.x"},{"key":"e_1_2_1_4_2","unstructured":"BetkeK BrewerGJ KirkmanHN LuzzatoL MotulskyAG RamotB SiniscalcoM BeutlerE StandleyCC:Standardization of procedures for the study of glucose\u20106\u2010phosphate dehydrogenase: Report of a WHO Scientific Group. 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