{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:17:04Z","timestamp":1791346624003,"version":"4.3.1"},"reference-count":6,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":6614,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1988,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We examined 55 patients with sickle cell anemia (HbSS) and 16 with hemoglobin SC disease (HbSC) to ascertain the presence of periodic microcirculatory flow (PMF) using laser\u2010Doppler velocimetry. Forty\u2010nine percent of patients with HbSS and 12.5% of HbSC patients had PMF on at least one occasion and in at least one site. The presence of PMF could be correlated with an increase in packed cell volume (PCV) and hemoglobin in individuals with HbSS and an increased white blood cell and platelet count in patients with HbSC. PMF may result from complex interactions among perfusion pressure, capillary tone, and the numbers and intrinsic properties of formed blood elements.<\/jats:p>","DOI":"10.1002\/ajh.2830280205","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:23:23Z","timestamp":1172057003000},"page":"92-94","source":"Crossref","is-referenced-by-count":12,"title":["Regional and temporal variation in oscillatory blood flow in sickle cell disease"],"prefix":"10.1002","volume":"28","author":[{"given":"Alan P.","family":"Kennedy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward F.","family":"Meydrech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin H.","family":"Steinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198412133112403"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197804000-00021"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1182\/blood.V63.6.1353.1353","article-title":"The Cooperative Society of Sickle Cell Disease: Effects of thalassemia and microcytosis upon the hematological and vaso\u2010occlusive severity of sickle cell anemia","volume":"63","author":"Steinberg MH","year":"1984","journal-title":"Blood"},{"key":"e_1_2_1_5_2","first-page":"H441","article-title":"Continuous measurement of tissue blood flow by laser\u2010Doppler spectroscopy","volume":"232","author":"Stern MD","year":"1977","journal-title":"Am J Physiol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12507665"},{"key":"e_1_2_1_7_2","volume-title":"Fundamentals of Biostatistics","author":"Rosner B","year":"1986"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830280205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830280205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T01:54:32Z","timestamp":1698026072000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830280205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,6]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988,6]]}},"alternative-id":["10.1002\/ajh.2830280205"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830280205","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,6]]}}}