{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T06:10:02Z","timestamp":1697955002702},"reference-count":5,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":6584,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1988,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients in the stable phase of chronic myelogenous leukemia (CML) are usually treated with busulfan. The bone marrow of patients with CML may be exquisitely sensitive to busulfan, and occasionally such patients develop pancytopenia, secondary to hypoplasia or aplasia of the bone marrow, which is presumed to be due to busulfan\u2010induced marrow toxicity. We report a case of Philadelphia chromosome\u2010positive CML who developed pancytopenia while being treated with busulfan; however, the patient's bone marrow was not hypoplastic or aplastic but rather hyperplastic with sideroblastic changes. Busulfan is not known to cause sideroblastic changes, so this was considered to herald a transformation into acute leukemia. Busulfan was stopped, and only supportive treatment was given. To our surprise approximately 22 weeks after busulfan was stopped, the sideroblastic changes had disappeared and the bone marrow again showed features of CML. This case suggests that busulfan may cause sideroblastic anemia.<\/jats:p>","DOI":"10.1002\/ajh.2830280316","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:21:18Z","timestamp":1172056878000},"page":"199-200","source":"Crossref","is-referenced-by-count":5,"title":["Busulfan\u2010induced sideroblastic anemia"],"prefix":"10.1002","volume":"28","author":[{"given":"Louis A.","family":"Fernandez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekram","family":"Zayed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1965.tb00085.x"},{"key":"e_1_2_1_3_2","first-page":"995","article-title":"Light\u2010chain disease (hypogammaglobulinemia and Bence Jones proteinuria) and sideroblastic anemia\u2014preleukemic chronic granulocytic leukemia","volume":"106","author":"MacSween JM","year":"1972","journal-title":"Can Med Assoc J"},{"key":"e_1_2_1_4_2","volume-title":"Clinical Hematology","author":"Wintrobe MM","year":"1981"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1986.tb04135.x"},{"key":"e_1_2_1_6_2","first-page":"1398","article-title":"Anemias sideroblastiques: etude clinique et hematologique de 57 patients","volume":"109","author":"Vetsch W","year":"1979","journal-title":"Schweiz Med Wochenschr"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830280316","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830280316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T11:45:36Z","timestamp":1697888736000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830280316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,7]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1988,7]]}},"alternative-id":["10.1002\/ajh.2830280316"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830280316","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,7]]}}}