{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:58:13Z","timestamp":1772819893507,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":6522,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1988,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report here the haplotypes of 10 Mstll\u2010defined SS patients and a S\/\u03b2<jats:sup>0<\/jats:sup> thalassemia from the Central African Republic, exhibiting 7 different atypical haplotypes that are different from the typical Bantu haplotype that characterize over 93% of the \u03b2<jats:sup>s<\/jats:sup> bearing chromosomes in that region of Africa. Of the seven atypical haplotypes, six can be easily interpreted as the result of recombination around the \u201chot spot\u201d 5\u2032 of the \u03b2 gene, between a typical Bantu haplotype and other haplotypes available in the normal population. Except for one case that requires further study, this result demonstrates that the main mutational event leading to sickle hemoglobin in Bantu\u2010speaking Africa was the mutation of the \u03b2 gene in a Bantu haplotype background.<\/jats:p>","DOI":"10.1002\/ajh.2830290117","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:15:59Z","timestamp":1172056559000},"page":"60-62","source":"Crossref","is-referenced-by-count":28,"title":["Atypical haplotypes linked to the \u03b2<sup>s<\/sup> gene in Africa are likely to be the product of recombination"],"prefix":"10.1002","volume":"29","author":[{"given":"Rao","family":"Srinivas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Dunda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajagopal","family":"Krishnamoorthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary E.","family":"Fabry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Georges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Labie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald L.","family":"Nagel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.6.1771"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198504043121403"},{"key":"e_1_2_1_4_2","first-page":"1239","article-title":"Nonuniform recombination within the human \u03b2\u2010globin gene cluster","volume":"36","author":"Chakravarti A","year":"1984","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1985.tb07412.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00286665"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/296627a0"},{"key":"e_1_2_1_8_2","unstructured":"PagnierRE: Heterogeneite genotypique et phenotypique de la drepanocytose en Afrique. These de Doctorat d'Etat et Sciences. Universite Paris VII 1985."},{"key":"e_1_2_1_9_2","first-page":"771","article-title":"Evidence supporting a single origin of the \u03b2c\u2010globin gene in blacks","volume":"37","author":"Boehm CD","year":"1985","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_10_2","first-page":"301","article-title":"Linkage between fetal A\u03b3 globin chain polymorphism and DNA polymorphism of the human \u03b2 gene cluster in \u03b2 thalassemia","volume":"2","author":"Beldjord C","year":"1984","journal-title":"Mol Biol Med"},{"key":"e_1_2_1_11_2","first-page":"191","article-title":"Multiple origins of the sickle mutation: Evidence from \u03b2 globin gene cluster polymorphisms","volume":"1","author":"Wainscoat JS","year":"1983","journal-title":"Mol Biol Med"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.3.853"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830290117","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830290117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T20:54:02Z","timestamp":1698008042000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830290117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,9]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,9]]}},"alternative-id":["10.1002\/ajh.2830290117"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830290117","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,9]]}}}