{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:28:27Z","timestamp":1790051307480,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":6492,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1988,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>According to previous clinical studies, the neurological manifestations observed in patients with thrombotic thrombocytopenic purpura (TTP) are considered to be transient. The introduction of plasma therapy in 1977 as major treatment modality for TTP has changed the prognosis of the disease. In a clinical survey of 38 patients with TTP who received plasma therapy, we have observed five patients who developed permanent neurological deficits despite their prompt recovery from TTP. In this study, we describe the new complication of TTP and summarize the neurological manifestations observed in these patients during their first episode of TTP and during the relapses, which occurred in 12 of them.<\/jats:p>","DOI":"10.1002\/ajh.2830290204","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:15:19Z","timestamp":1172056519000},"page":"74-78","source":"Crossref","is-referenced-by-count":28,"title":["Permanent neurological complications in patients with thrombotic thrombocytopenic purpura"],"prefix":"10.1002","volume":"29","author":[{"given":"Dina","family":"Ben\u2010Yehuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yossef","family":"Michaeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amiram","family":"Eldor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-196603000-00003"},{"key":"e_1_2_1_3_2","first-page":"287","volume-title":"Progress in Thrombosis and Haemostasis","author":"Bukowski RM","year":"1982"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1182\/blood.V56.2.302.302","article-title":"Thrombotic thrombocytopenic purpura: A ten\u2010year experience","volume":"56","author":"Cuttner J","year":"1980","journal-title":"Blood"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1925.00120130092009"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1005106"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198111000-00003"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1968.00470340044003"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197712222972507"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5966.317"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198212023072306"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90753-4"},{"key":"e_1_2_1_13_2","first-page":"418","article-title":"Chronic thrombotic thrombocytopenic purpura: Report of a case with five relapses and review of the literature","volume":"45","author":"Cuttner J","year":"1978","journal-title":"Mt Siani J Med"},{"key":"e_1_2_1_14_2","first-page":"1070","article-title":"Recurrences of acute thrombotic thrombocytopenic purpura","volume":"66","author":"Rice L","year":"1985","journal-title":"Blood"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0308-2261(18)30024-9","article-title":"Thrombotic thrombocytopenic purpura and haemolytic\u2010uremic syndrome: Evolving concepts of pathogenesis and therapy","volume":"15","author":"Byrnes JJ","year":"1986","journal-title":"Cliln Haeamatol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1182\/blood.V53.2.333.333","article-title":"Presence of a platelet aggregating factor in the plasma of patients with thrombotic thrombocytopenic purpura (TTP) and its inhibition by normal plasma","volume":"53","author":"Lian EC\u2010Y","year":"1979","journal-title":"Blood"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1005110"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112107"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111670"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830290204","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830290204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T02:56:08Z","timestamp":1697856968000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830290204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,10]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988,10]]}},"alternative-id":["10.1002\/ajh.2830290204"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830290204","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,10]]}}}