{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:21:08Z","timestamp":1760188868289},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":6492,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1988,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe the first three patients with a large granular lymphocytosis\/lymphocytic leukemia and another blood malignancy. In two, a myeloproliferative disorder developed soon after the diagnosis of abnormal proliferation of large granular lymphocytes\u2010natural killer (LGL\u2010NK) cells, a myelodysplastic syndrome evolving to acute leukemia and a Philadelphia\u2010positive chronic myelogenous leukemia. In these cases, LGLs expressed the phenotype of CD2 + NK and CD3 \u2010 NK cells, respectively, and were clonal in the first patient as demonstrated by T\u2010cell receptor gene rearrangement study. In the third case, a similarly clonal excess of LGLs, phenotypically CD3 + NK cells, was detected following a diagnosis of B\u2010cell hairy\u2010cell leukemia. Clinically, the concurrence of LGL proliferation and other leukemia did not seem to confer a worse prognosis on the patients. Although an association by chance remains a possible explanation, a common origin from an altered precursor cell for both myeloid and LGL proliferations in the first two cases is discussed, whereas in the third it might be related to the severe immune derangement frequently observed in hairy\u2010cell leukemia.<\/jats:p>","DOI":"10.1002\/ajh.2830290206","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:15:19Z","timestamp":1172056519000},"page":"85-93","source":"Crossref","is-referenced-by-count":16,"title":["Association of large granular lymphocyte\/natural killer cell proliferative disease and second hematologic malignancy"],"prefix":"10.1002","volume":"29","author":[{"given":"Renato","family":"Bassan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Rambaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Allavena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Abbate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basilio","family":"Marini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziano","family":"Barbui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1182\/blood.V64.6.1146.1146","article-title":"T\u03b3\u2010lymphoproliferative disease and related disorders in humans and experimental animals: a review of the clinical, cellular, and functional characteristics","volume":"64","author":"Reynolds CW","year":"1984","journal-title":"Blood"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-102-2-169"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.162.6.2156"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00919136"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00320116"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00321070"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(77)90422-3"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1985.tb02865.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1985.tb07485.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1987.tb04163.x"},{"key":"e_1_2_1_12_2","first-page":"489","article-title":"Human natural killer cells: biologic and pathologic aspects","volume":"50","author":"Trinchieri G","year":"1984","journal-title":"Lab Invest"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/B978-0-12-341370-3.50046-4","volume-title":"Mechanisms of cytotoxicity by NK cells","author":"Lotzov\u00e0 E","year":"1985"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910370106"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1986.tb01956.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(86)90287-X"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.4049\/jimmunol.136.4.1260","article-title":"Modulation of in vitro myelopoiesis by LGL: Different effects on early and late progenitor cells","volume":"136","author":"Matera L","year":"1986","journal-title":"J Immunol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"566","DOI":"10.4049\/jimmunol.134.2.699","article-title":"Common precursor pool marker for allospecific (CTL) and nonspecific (NK and activated) cytotoxic cells in the bone marrow","volume":"134","author":"Nieminen P","year":"1985","journal-title":"J Immunol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0167-5699(86)90099-X","article-title":"NK lineage and target specificity: a unifying concept","volume":"7","author":"Kaplan J","year":"1986","journal-title":"Immunol Today"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-4850-7_13"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1984.tb06060.x"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830220104"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"180","DOI":"10.4049\/jimmunol.133.1.180","article-title":"The Fc receptor for IgG on human natural killer cells: phenotypic, functional, and comparative studies with monoclonal antibodies","volume":"133","author":"Perussia B","year":"1984","journal-title":"J Immunol"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1986.tb01779.x"},{"issue":"1","key":"e_1_2_1_25_2","first-page":"79a","article-title":"Natural killer (NK) cells are clonal in chronic myelogenous leukaemia","volume":"64","author":"Prchal JT","year":"1984","journal-title":"Blood"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910370502"},{"key":"e_1_2_1_27_2","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1182\/blood.V64.1.288.288","article-title":"Human large granular lymphocytes and their relationship to natural killer cell activity in various disease states","volume":"64","author":"Gastl G","year":"1984","journal-title":"Blood"},{"key":"e_1_2_1_28_2","first-page":"696","article-title":"Permanent large granular lymphocytosis in the blood of splenectomized individuals without concomitant increase of in vitro natural killer cell cytotoxicity","volume":"63","author":"Kelemen E","year":"1986","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_29_2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1182\/blood.V68.1.293.293","article-title":"\u03b1\u2010interferon activates the natural killer system in patients with hairy cell leukemia","volume":"68","author":"Semenzato G","year":"1986","journal-title":"Blood"},{"key":"e_1_2_1_30_2","first-page":"394","article-title":"Cellular origin of hairy cell leukemia: malignant B cells that express receptors for T cell growth factor","volume":"11","author":"Korsmeyer SJ","year":"1984","journal-title":"Semin Oncol"},{"issue":"1","key":"e_1_2_1_31_2","first-page":"175a","article-title":"Hairy cell leukemia (HCL) and second neoplasms","volume":"66","author":"Han T","year":"1985","journal-title":"Blood"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19871001)60:7<1537::AID-CNCR2820600721>3.0.CO;2-S"},{"key":"e_1_2_1_33_2","first-page":"392","article-title":"Phenotypic and functional characterization of the circulating NK compartment in hairy cell leukaemia","volume":"64","author":"Foa R","year":"1986","journal-title":"Clin Exp Immunol"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830290206","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830290206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T02:56:19Z","timestamp":1697856979000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830290206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,10]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988,10]]}},"alternative-id":["10.1002\/ajh.2830290206"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830290206","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,10]]}}}