{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T07:54:47Z","timestamp":1698134087170},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":6431,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1988,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic lymphocytic leukemia of B\u2010cell type (B\u2010CLL) is a malignant disease characterized by monoclonal proliferation of small lymphocytes of B\u2010cell origin, usually associated with suppression of polyclonal B\u2010cell activation (i.e., proliferation and differentiation). Normal human B\u2010cell proliferation is controlled by different T\u2010cell\u2010derived lymphokines, including interleukin 2 (IL2) and gamma interferon (\u03b3\u2010IFN), that account for the majority of the B\u2010cell growth factor (BCGF) activity produced by mitogen\u2010activated peripheral blood mononuclear cells (PBMCs). We have previously shown an increased and dysregulated secretion of IL2 in peripheral blood from patients with BCLL. BCGF, IL2, and \u03b3\u2010IFN productions by phytohemagglutinin (PHA)\u2010stimulated PBMCs were investigated in 13 patients with active untreated B\u2010CLL and 11 healthy donors. BCLL PBMCs produced a significant amount of BCGF (6 U\/ml) despite the low percentage of T cells (10%) associated with this disease as compared with that found in healthy donors (61%). BCGF production in normal controls and B\u2010CLL patients was tripled after irradiation of PBMCs or addition of indomethacin. \u03b3\u2010IFN secretion in B\u2010CLL patients was decreased when compared with normal controls. Therefore, when \u03b3\u2010IFN was calculated per fixed number of T cells, production was significantly higher in B\u2010CLL patients than in normal controls, showing a dilution of the productive cells. This study suggests that T cells from B\u2010CLL patients are functional in terms of BCGF production despite their decreased percentage and abnormalities in surface markers.<\/jats:p>","DOI":"10.1002\/ajh.2830290402","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:50:58Z","timestamp":1172058658000},"page":"183-188","source":"Crossref","is-referenced-by-count":2,"title":["Production of B\u2010cell growth factor interleukin 2 and gamma interferon by peripheral blood lymphocytes from patients with chronic lymphocytic leukemia of B\u2010cell 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