{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:37:34Z","timestamp":1790386654979,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":6431,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1988,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sera from 23 individuals with Gaucher disease (GD) were analyzed for hypergammaglobulinemia and oligoclonal and monoclonal gammopathies. Serum IgG level was elevated in 15\/23 (65%) patients, and a diffuse hypergammaglobulinemia was present in 10\/23 (43%) patients. An oligoclonal gammopathy was noted in six patients, and a monoclonal gammopathy in two. Lymphocyte subset analysis was also carried out in eight individuals with GD. Four of five individuals showed increased surface Ig\u2010positive lymphocytes, while 7\/7 were positive for either increased CD19\u2010 and\/or CD20\u2010positive lymphocytes. An eighth patient was found to have a B\u2010cell leukemia. Statistical analysis of <jats:italic>k<\/jats:italic> and \u03bb histograms were suggestive of a monoclonal excess. However, restriction enzyme analysis of four individuals with GD and increased B cells failed to show any evidence of Ig gene rearrangements. Serum Ig abnormalities and perhaps B\u2010cell lymphocytosis appear to be common in the GD patient population and are not associated with circulating monoclonal lymphocytes.<\/jats:p>","DOI":"10.1002\/ajh.2830290403","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:50:58Z","timestamp":1172058658000},"page":"189-194","source":"Crossref","is-referenced-by-count":74,"title":["Polyclonal B\u2010cell lymphocytosis and hypergammaglobulinemia in patients with gaucher disease"],"prefix":"10.1002","volume":"29","author":[{"given":"G. E.","family":"Marti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. T.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. M.","family":"Papadopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Filling\u2010Katz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Barton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. A.","family":"Fleischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. R.","family":"Gralnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"842","volume-title":"The Metabolic Basis of Inherited Disease","author":"Brady RO","year":"1983"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1182\/blood.V31.5.633.633","article-title":"Immunoglobulin abnormalities in Gaucher's disease: Report of 16 cases","volume":"31","author":"Pratt PW","year":"1968","journal-title":"Blood"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000207271"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1982.tb02120.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1980.00330190127042"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1982.00340250195035"},{"key":"e_1_2_1_8_2","first-page":"122","article-title":"Multiple myeloma complicating Gaucher's disease","volume":"136","author":"Miller W","year":"1982","journal-title":"West J Med"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1979.tb00419.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/4.8.28"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(68)80284-7"},{"key":"e_1_2_1_12_2","first-page":"460","article-title":"Amyloidosis: An unusual complication of Gaucher's disease","volume":"102","author":"Dikman SH","year":"1978","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000207705"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711160403"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-89-5-639"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840715)54:2<312::AID-CNCR2820540222>3.0.CO;2-I"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840715)54:2<312::AID-CNCR2820540222>3.0.CO;2-I"},{"key":"e_1_2_1_18_2","unstructured":"PaulsonJA MartiGE FinkJK SatoN SchoenM KarcherDS: Richter's like transformation complicating Gaucher's disease.Hematologic Pathol(accepted for publication)."},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/clinchem\/28.4.707","article-title":"Incidence of \u03b3\u2010globulin banding in a healthy population by high\u2010resolution electrophoresis","volume":"28","author":"Papadopolous NM","year":"1982","journal-title":"Clin Chem"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830200107"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197906213002501"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830180407"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198312293092601"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/290368a0"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.11.7096"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110770"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(81)90400-1"},{"key":"e_1_2_1_28_2","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.4049\/jimmunol.134.5.3036","article-title":"Lymphocyte function in human bone marrow: I. Characterization of two T cell populations regulating immunoglobulin secretion","volume":"134","author":"Mills GB","journal-title":"J Immunol"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712173172503"},{"key":"e_1_2_1_30_2","first-page":"110","article-title":"Lymphocyte subsets in human peripheral blood after splenectomy and autotransplantation of splenic tissue","volume":"104","author":"D\u00fcrig M","year":"1984","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2448875"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830290403","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830290403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T04:07:19Z","timestamp":1695787639000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830290403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,12]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1988,12]]}},"alternative-id":["10.1002\/ajh.2830290403"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830290403","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,12]]}}}