{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T04:10:42Z","timestamp":1707624642197},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":6431,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1988,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Yeast\u2010recombinant vaccines against hepatitis B virus (HBV) are now available, but there is no information about whether or not they are immunogenic in patients with hemophilia and other congenital bleeding disorders. Twenty micrograms of a recombinant vaccine expressing the adw serotype of the hepatitis B surface antigen (HBsAg) were given to 41 patients negative for HBV markers and again after 1 and 6 months. Ten percent of the vaccinees had anti\u2010hepatitis B surface antibody (anti\u2010HBs) responses, with titers of 10 mlU\/ml or more, 1 month after the first dose of vaccine. The percentage of anti\u2010HBs\u2010positive patients increased to 54% after the second dose and to 98% after the third dose, with only one non\u2010responder. Hence, the recombinant vaccine was immunogenic, with percentages of seroconversion and anti\u2010HBs titers similar to those achieved with plasma\u2010derived vaccines.<\/jats:p>","DOI":"10.1002\/ajh.2830290407","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:50:58Z","timestamp":1172058658000},"page":"211-214","source":"Crossref","is-referenced-by-count":11,"title":["Immunogenicity of a recombinant hepatitis B vaccine in hemophiliacs"],"prefix":"10.1002","volume":"29","author":[{"given":"P. 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