{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T00:22:43Z","timestamp":1698538963418},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":6400,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Evolution of low\u2010grade Non\u2010Hodgkin Lymphoma (NHL) into a more aggressive neoplasm is a common, well\u2010documented event in NHL. The reverse process, in which a less aggressive component becomes evident during the course of treatment for a highergrade NHL, has only recently been recognized. This lymphoma \u201cdowngrading\u201d has been reported at the time of relapse in both radiation\u2010 and chemotherapy\u2010treated patients who initially presented with high\u2010 or intermediate\u2010grade lymphoma. The etiology of this unusual transformation has not yet been determined. We present the clinical, morphologic, immunologic, and flow\u2010cytometric features of a patient with diffuse immunoblastic lymphoma who achieved a complete response to chemotherapy and then relapsed with follicular small\u2010cleaved\u2010cell lymphoma 3 years later. Morphologic and immunophenotypic findings suggest that both immunoblasts and small cleaved cells were present in the initial biopsy. DNA content analysis of the initial and relapse biopsies suggests that the immunoblastic component was more susceptible than the small cleaved cells to the chemotherapy that the patient received. Successful eradication of the rapidly proliferating immunoblasts with survival of less rapidly proliferating small cleaved cells may account for the unusual histologic transformation seen in this case.<\/jats:p>","DOI":"10.1002\/ajh.2830300108","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:50:35Z","timestamp":1172058635000},"page":"36-41","source":"Crossref","is-referenced-by-count":17,"title":["High\u2010grade non\u2010Hodgkin lymphoma relapsing as low\u2010grade follicular lymphoma: So\u2010called downgraded lymphoma"],"prefix":"10.1002","volume":"30","author":[{"given":"Daniel P.","family":"Kerrigan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Foucar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Dressler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830801)52:3<393::AID-CNCR2820520302>3.0.CO;2-M"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V59.2.258.258"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198412063112303"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840301)53:5<1109::AID-CNCR2820530516>3.0.CO;2-O"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(84)80327-5"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/89.1.106"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000205952"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-94-2-218"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-198610000-00012"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831015)52:8<1356::AID-CNCR2820520803>3.0.CO;2-M"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860115)57:2<288::AID-CNCR2820570217>3.0.CO;2-5"},{"key":"e_1_2_1_13_2","first-page":"497","article-title":"Immunohistochemical analysis of human lymphomas with monoclonal antibodies to B cell and Ia antigens reactive in paraffin sections","volume":"52","author":"Marder RJ","year":"1985","journal-title":"Lab Invest"},{"key":"e_1_2_1_14_2","first-page":"1","article-title":"Monoclonal antibodies marking T lymphocytes in paraffinembedded tissue","volume":"127","author":"Linder J","year":"1987","journal-title":"Am J Pathol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/31.11.6619538"},{"key":"e_1_2_1_16_2","first-page":"5294","article-title":"Evaluation of a modeling system for S\u2010phase estimation in breast cancer by flow cytometry","volume":"47","author":"Dressler LG","year":"1987","journal-title":"Cancer Res"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(87)90092-7"},{"key":"e_1_2_1_18_2","first-page":"5010","article-title":"Cellular DNA of human neoplastic B\u2010cells measured by flow cytometry","volume":"44","author":"Braylan RC","year":"1984","journal-title":"Cancer Res"},{"key":"e_1_2_1_19_2","first-page":"45","volume-title":"Pharmacologic Principles of Cancer Treatment","author":"Chabner B","year":"1982"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810415)47:8<2022::AID-CNCR2820470820>3.0.CO;2-V"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830300108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830300108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T12:13:39Z","timestamp":1697976819000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830300108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1989,1]]}},"alternative-id":["10.1002\/ajh.2830300108"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830300108","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,1]]}}}