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We describe here the first case of hybrid acute leukemia in an HIV\u2010antibody\u2010positive patient as well as the first hybrid involving B\u2010cell (Burkitt) acute lymphocytic leukemia and acute myelomonocytic leukemia proven by cytochemical, immunologic, and cytogenetic methods. This case illustrates the increasingly complex difficulties in the diagnosis and treatment of AIDS\u2010related malignancies.<\/jats:p>","DOI":"10.1002\/ajh.2830300410","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:47:48Z","timestamp":1172058468000},"page":"240-247","source":"Crossref","is-referenced-by-count":13,"title":["Hybrid acute leukemia in an HIV\u2010antibody\u2010positive patient"],"prefix":"10.1002","volume":"30","author":[{"given":"Jay E.","family":"Gold","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvid","family":"Babu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Penchaszadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Castella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violette","family":"Ghali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph","family":"Zalusky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80288-1"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(83)90021-8"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1182\/blood.V51.6.1051.1051","article-title":"Evidence for distinct lymphocytic and monocytic populations in a patient with terminal transferase\u2010positive acute leukemia","volume":"51","author":"Mertelsmann R","year":"1978","journal-title":"Blood"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198703263161308"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V66.5.1115.1115"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V67.1.1.1"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(84)90046-8"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1987.tb06851.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2900050305"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198704303161802"},{"key":"e_1_2_1_12_2","first-page":"140a","article-title":"Simultaneous expression of common acute lymphoblastic leukemia antigen and myeloperoxidase: Evidence for mixed phenotypic expression in acute leukemia","volume":"60","author":"Stass SA","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1182\/blood.V63.5.1023.1023","article-title":"Heavy chain immunoglobulin gene rearrangements in acute non\u2010lymphocytic leukemia","volume":"63","author":"Rovigatti M","year":"1984","journal-title":"Blood"},{"key":"e_1_2_1_14_2","first-page":"757","article-title":"Rearrangement of immunoglobulin and T\u2010cell antigen receptor genes in acute myeloid leukemia with lymphoid\u2010associated markers","volume":"1","author":"Norton JD","year":"1987","journal-title":"Leukemia"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00320001"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1985.tb02857.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1182\/blood.V65.1.142.142","article-title":"Simultaneous or sequential expression of lymphoid and myeloid phenotypes in acute leukemia","volume":"65","author":"Neame PB","year":"1985","journal-title":"Blood"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1986.tb02204.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830280208"},{"key":"e_1_2_1_20_2","first-page":"664","article-title":"Non\u2010Hodgkin's lymphoma in AIDS: Report of 11 cases and literature review","volume":"53","author":"Mernick MH","year":"1986","journal-title":"Mt Sinai J Med (NY)"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880601)61:11<2318::AID-CNCR2820611129>3.0.CO;2-3"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1200\/JCO.1986.4.5.737","article-title":"B\u2010cell acute lymphocytic leukemia in adults. 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