{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:22:43Z","timestamp":1788344563580,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":6249,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1989,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>One hundred twenty\u2010five granulocyte transfusions were given concurrently with amphotericin B to 31 granulocytopenic patients with acute leukemia during a four year period. Twenty\u2010six patients had culture\u2010documented, and 5 had presumed fungal infections; pulmonary infiltrates were present in 26 patient courses. Eight patients developed pulmonary deterioration temporally related to therapy with amphotericin, granulocyte transfusions, or both. One event occurred following amphotericin alone. Three additional reactions occurred in alloimmunized patients with antibodies to human leukocyte antigens (HLA) who received random donor granulocytes, which may indicate a potential mechanism for the pulmonary reactions. Two reactions potentially represent an adverse interaction between amphotericin and granulocytes, but these were reversible and were not unlike reactions expected with each modality alone. Our data fail to document a specific detrimental interaction between granulocyte transfusions and amphotericin beyond the reactions associated with each modality, and the data suggest that other clinical factors, particularly infection and alloimmunization, also contribute to pulmonary decompensation. We nevertheless recommend great care and attention be given to administering these modalities in the setting of severely ill patients.<\/jats:p>","DOI":"10.1002\/ajh.2830310206","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:45:25Z","timestamp":1172058325000},"page":"102-108","source":"Crossref","is-referenced-by-count":46,"title":["Granulocyte transfusion therapy and amphotericin B: Adverse reactions?"],"prefix":"10.1002","volume":"31","author":[{"given":"Janice P.","family":"Dutcher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Kendall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dottie","family":"Norris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Schiffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Aisner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Wiernik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198105143042001"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1182\/blood.V57.1.90.90","article-title":"Concomitant administration of granulocyte transfusions and amphotericin B in neutropenic patients: Absence of significant pulmonary toxicity","volume":"57","author":"Dana BW","year":"1981","journal-title":"Blood"},{"key":"e_1_2_1_4_2","first-page":"585","article-title":"Pulmonary reactions associated with amphotericin B and leukocyte transfusions. (Letter to the Editor)","volume":"305","author":"DeGregorio MW","year":"1981","journal-title":"N Engl J Med"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1976.16577039299.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V54.1.254.254"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(79)90002-X"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1182\/blood.V52.1.249.249","article-title":"Development of a practical oral dexamethasone premedication schedule leading to improved granulocyte yields with the continuous\u2010flow centrifugal blood cell separator","volume":"52","author":"Winton EF","year":"1978","journal-title":"Blood"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.1974.tb04545.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1975.15676082230.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1977.17578014584.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1979.19179160275.x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-196811000-00006"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1182\/blood.V62.2.354.354","article-title":"Alloimmunization prevents the migration of transfused indium\u2010III\u2010labeled granulocytes to sites of infection","volume":"62","author":"Dutcher JP","year":"1983","journal-title":"Blood"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1982.22583017461.x"},{"key":"e_1_2_1_16_2","first-page":"177a","article-title":"Pulmonary retention of indium\u2010III\u2010labeled granulocytes in alloimmunized patients","volume":"60","author":"Dutcher JP","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V54.4.766.766"},{"key":"e_1_2_1_18_2","first-page":"72","article-title":"Quantitation of lymphocytes in bronchoalveolar lavage from rats after intravascular injection of endotoxin","volume":"129","author":"Chang JC","year":"1984","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1182\/blood.V58.3.518.518","article-title":"Amphotericin B promotes leukocyte aggregation of nylon\u2010wool\u2010fiber\u2010treated polymorphonuclear leukocytes","volume":"58","author":"Boxer LA","year":"1981","journal-title":"Blood"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1182\/blood.V39.4.554.554","article-title":"Granulocyte collection by continuous flow filtration leukapheresis","volume":"39","author":"Herzig GP","year":"1972","journal-title":"Blood"},{"key":"e_1_2_1_21_2","first-page":"901","article-title":"Functional abnormalities of human neutrophils collected by continuous flow filtration leukapheresis","volume":"46","author":"Wright DG","year":"1975","journal-title":"Blood"},{"key":"e_1_2_1_22_2","first-page":"1054","article-title":"Complement mediated granulocyte and pulmonary dysfunction during nylon fiber leukapheresis","volume":"46","author":"Fehr J","year":"1975","journal-title":"Blood"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1182\/blood.V48.2.315.315","article-title":"In vitro function and post\u2010transfusion survival of granulocytes collected by continuous flow centrifugation and by filtration leukapheresis","volume":"48","author":"McCullough J","year":"1976","journal-title":"Blood"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1978.tb07114.x"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830310206","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830310206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T11:16:35Z","timestamp":1697973395000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830310206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,6]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,6]]}},"alternative-id":["10.1002\/ajh.2830310206"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830310206","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,6]]}}}