{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:35:50Z","timestamp":1788568550253,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":6219,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1989,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Desmopressin (DDAVP), a synthetic vasopressin, temporarily corrects bleeding abnormalities associated with mild hemophilia A, von Willebrand disease, and disorders of platelet function. The side effects of DDAVP are considered benign although most of its use has been in adults and older children. We report four children under the age of 2 years who became hyponatremic after intravenous DDAVP administration (0.3 \u03bcg\/kg). Three of them developed grand mal seizures. A review of the literature and these cases indicate that associated risk factors for hyponatremia after DDAVP administration include stress, surgery, anesthesia and narcotics (endogenous release of antidiuretic hormone), vomiting (loss of Na+), liver disease (hindered metabolism of DDAVP), renal tubular acidosis (chronically low serum Na+), multiple doses of DDAVP, and overhydration with hyponatremic fluids. DDAVP is not a benign drug in this age group and shows a serious potential for hyponatremia and seizures. Fluid restriction, avoidance of hyponatremic solutions, and close monitoring of serum electrolytes and urine output for at least 15\u201320 hr after the administration of DDAVP, when used in children under the age of 2 years, is warranted.<\/jats:p>","DOI":"10.1002\/ajh.2830310310","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:44:46Z","timestamp":1172058286000},"page":"199-202","source":"Crossref","is-referenced-by-count":129,"title":["Hyponatremia and seizures in young children given ddavp"],"prefix":"10.1002","volume":"31","author":[{"given":"Thomas J.","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan C.","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Ambruso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Hathaway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198301063080102"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1981.tb02789.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80526-5"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91197-7"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000182801"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-103-1-6"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(87)80319-4"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198605293142202"},{"key":"e_1_2_1_10_2","first-page":"207","volume-title":"Harriet Lane Handbook","author":"Bitler JB","year":"1981"},{"key":"e_1_2_1_11_2","first-page":"187","volume-title":"Review of Medical Physiology","author":"Ganong WF","year":"1981"},{"key":"e_1_2_1_12_2","first-page":"375","article-title":"Clinical experience with arginine vasopressin (DDAVP) in von Willebrand's disease and mild haemophilia","volume":"92","author":"Ockelford PA","year":"1980","journal-title":"N Z Med J"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-103-2-228"},{"key":"e_1_2_1_14_2","first-page":"1034","volume-title":"Hemostasis and Thrombosis: Basic Principles and Clinical Practice","author":"Ratnoff OD","year":"1987"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198801143180215"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830280115"},{"key":"e_1_2_1_17_2","unstructured":"BonaRD WeinsteinRE WeismanSJ AltmanA QuinnJ BartolomeoA RicklesFR: DDAVP and the risks of hyponatremia. Presented at the Annual Meeting of the National Hemophilia Foundation Anaheim CA October 15 1988 and personal communication with Dr. Ralph Weinstein."},{"key":"e_1_2_1_18_2","first-page":"19","article-title":"Drug induced changes in water excretion","volume":"14","author":"Gardenschwartz MH","year":"1981","journal-title":"Kidney"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91469-6"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.293.6543.353"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1984.tb09911.x"},{"key":"e_1_2_1_22_2","first-page":"1797","volume-title":"Physicians Desk Reference","year":"1988"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1981.199"},{"key":"e_1_2_1_24_2","first-page":"443","article-title":"The 24 hour true endogenous creatinine clearance in infants and children without renal disease","volume":"48","author":"Winberg J","year":"1959","journal-title":"Acta Paediatr Scand"},{"key":"e_1_2_1_25_2","first-page":"279A","article-title":"Failure of response to DDAVP in children less than one year of age","volume":"20","author":"Gill JC","year":"1986","journal-title":"Pediatr Res"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830310310","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830310310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T02:19:21Z","timestamp":1697941161000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830310310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,7]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1989,7]]}},"alternative-id":["10.1002\/ajh.2830310310"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830310310","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,7]]}}}