{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T06:54:17Z","timestamp":1698044057664},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":6219,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1989,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In an in vitro progenitor cell culture system, a significant amount of normal hemoglobin (Hb A) synthesis was observed in a transfused sickle cell anemia (SS) patient, indicating the contribution of stem cells obtained from the normal donor's blood cells. As this study was done long after the last blood transfusion (&gt; 100 days), the survival of the donor's stem cells would indicate their repopulating the recipient's bone marrow. On extending the study to a few other transfused SS patients who had received multiple blood transfusions at frequent intervals, no such synthesis of Hb A was observed. A loss of repopulating ability of the donor's stem cells with frequent transfusions at short intervals is suggested as a possible explanation, with a gradual development of immune response against these cells as a second possibility. The differences in the survival of the donor's stem cells would thus appear to have some reflection on the frequency of blood transfusions required by an individual patient.<\/jats:p>","DOI":"10.1002\/ajh.2830310312","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:44:46Z","timestamp":1172058286000},"page":"208-210","source":"Crossref","is-referenced-by-count":1,"title":["Hemoglobin synthesis in BFU\u2010E colonies derived from transfused blood in a sickle cell anemia patient"],"prefix":"10.1002","volume":"31","author":[{"given":"Kabita","family":"Bhaumik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"655","volume-title":"Hematology of Infancy and Childhood","author":"Platt OS","year":"1987"},{"key":"e_1_2_1_3_2","volume-title":"Sickle Cell Disease","author":"Serjeant GR","year":"1985"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/256041a0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1182\/blood.V67.5.1404.1404","article-title":"High fetal hemoglobin production in sickle cell anemia in the Eastern Province of Saudi Arabia is genetically determined","volume":"67","author":"Miller BA","year":"1986","journal-title":"Blood"},{"key":"e_1_2_1_6_2","unstructured":"BhaumikK: \u201cIn Vitro Synthesis of Globin Chains in Erythroid Progenitor Cells From Sickle Cell Anemia Patients.\u201d Doctor of Philosophy Dissertation Medical College of Georgia 1988."},{"key":"e_1_2_1_7_2","first-page":"174","article-title":"A new high performance liquid chromatographic procedure for the separation and quantitation of various hemoglobin variants in adults and newborn babies","volume":"102","author":"Wilson JB","year":"1983","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/01483918408068849"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.147.5.1526"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1030640104"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830310312","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830310312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T02:20:30Z","timestamp":1697941230000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830310312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,7]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1989,7]]}},"alternative-id":["10.1002\/ajh.2830310312"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830310312","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,7]]}}}