{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:49:36Z","timestamp":1774140576688,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":6219,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1989,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A case of acute, transient agranulocytosis and thrombocytopenia associated with ingestion of dipyrone is reported. This once widely used analgesic, which is now banned in the United States, was obtained by the patient as \u201caspirin\u201d while traveling in Mexico. Studies of the effects of this patient's serum on purified CD34+ marrow cells, which were highly enriched for hematopoietic progenitors, showed not only a drug\u2010dependent suppression of the in vitro growth of myeloid progenitors, as has been reported previously, but also a drug\u2010dependent suppression of primitive multipotential progenitors (CFU\u2010Mix) and erythroid progenitors (BFU\u2010E). These findings indicate that autoimmune, antibody\u2010hapten interactions which have been reported to occur in dipyrone\u2010 and aminopyrine\u2010induced agranulocytosis are not restricted to the neutrophil lineage.<\/jats:p>","DOI":"10.1002\/ajh.2830310314","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:44:46Z","timestamp":1172058286000},"page":"213-215","source":"Crossref","is-referenced-by-count":21,"title":["Agranulocytosis associated with \u201cmexican aspirin\u201d (dipyrone): Evidence for an autoimmune mechanism affecting multipotential hematopoietic progenitors"],"prefix":"10.1002","volume":"31","author":[{"given":"J. B.","family":"Hargis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. F.","family":"La Russa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Redmond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. W.","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. G.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"2183","article-title":"The relation of amidopyrine and the barbituric acid derivitives to granulocytopenia","volume":"102","author":"Council on Pharmacy and Chemistry","year":"1934","journal-title":"JAMA"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1935.92760380004011"},{"key":"e_1_2_1_4_2","first-page":"225","article-title":"Causes of agranulocytosis in a hospital population: Identification of dipyrone as an important causative agent","volume":"19","author":"Shiner E","year":"1983","journal-title":"Isr J Med Sci"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6040.850-a"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1182\/blood.V72.1.273.273","article-title":"An analysis of the multilineage production of human hematopoietic progenitors in long\u2010term bone marrow culture","volume":"72","author":"Meagher RC","year":"1988","journal-title":"Blood"},{"issue":"5","key":"e_1_2_1_7_2","first-page":"321a","article-title":"Large\u2010scale purification and characterization of CD34\u2010positive hematopoietic progenitor cells","volume":"70","author":"Kessler SW","year":"1987","journal-title":"Blood"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V52.6.1243.1243"},{"key":"e_1_2_1_9_2","first-page":"773","volume-title":"Hematology","author":"Finch SC","year":"1983"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198101000-00001"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1985.tb02813.x"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830310314","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830310314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T02:20:33Z","timestamp":1697941233000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830310314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,7]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1989,7]]}},"alternative-id":["10.1002\/ajh.2830310314"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830310314","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,7]]}}}