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Following treatment, prothrombin time and activated partial thromboplastin time were significantly prolonged, while a marked decrease in fibrinogen levels was observed. The values for cross\u2010linked fibrin degradation products, however, remained within normal limits during treatment, which excluded the possibility of disseminated intravascular coagulation. The concentrations of coagulation inhibitors (antithrombin III, protein C, and protein S), plasminogen, and \u03b1<jats:sub>2<\/jats:sub> antiplasmin also significantly decreased; however, levels of both tissue\u2010type plasminogen activator and plasminogen activator inhibitor, which are synthesized in endothelial cells, increased during the treatment.<\/jats:p><jats:p>Although a decrease was observed in concentrations of many coagulation factors, including subunits A and B of factor XIII, the activity and antigenicity of factor VII significantly increased following the treatment. From this study, we concluded that these hemostatic abnormalities caused by the administration of L\u2010asparaginase produced a labile condition that easily inclines to bleeding or thrombosis.<\/jats:p>","DOI":"10.1002\/ajh.2830320105","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:42:15Z","timestamp":1172058135000},"page":"20-23","source":"Crossref","is-referenced-by-count":26,"title":["Changes in hemostatic and fibrinolytic proteins in patients receiving L\u2010asparaginase therapy"],"prefix":"10.1002","volume":"32","author":[{"given":"Masanori","family":"Saito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidesaku","family":"Asakura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Jokaji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chika","family":"Uotani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Kumabashiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamotsu","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196911062811902"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-74-6-893"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197710)40:4<1398::AID-CNCR2820400406>3.0.CO;2-#"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80536-2"},{"key":"e_1_2_1_6_2","first-page":"116","article-title":"Hemostatic changes in children with acute lymphoblastic leukemia treated according to two different L\u2010asparaginase schedules","volume":"8","author":"Miniero R","year":"1986","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"e_1_2_1_7_2","first-page":"377","article-title":"L\u2010asparaginase\u2010induced coagulopathy in children with acute lymphoblastic leukemia","volume":"13","author":"Miniero R","year":"1987","journal-title":"Drugs Expl Clin Res"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000205234"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1093\/clinchem\/30.9.1512","article-title":"Application of enzyme immunoassays to coagulation testing","volume":"30","author":"Amiral J","year":"1984","journal-title":"Clin Chem"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1093\/clinchem\/30.5.814","article-title":"Performance characteristics of a commercial kit for assay of factor VIII\u2010related antigen","volume":"30","author":"Cejka J","year":"1984","journal-title":"Clin Chem"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(66)90246-6"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(88)90196-X"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)67353-3"},{"key":"e_1_2_1_14_2","unstructured":"KoikeY WakabayashiK SumiY IchikawaY:Determination of free protein S by ELISA using monoclonal antibodies. 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