{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T02:57:38Z","timestamp":1770433058893,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":6157,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1989,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Four members in two generations of a Polish\u2010American family exhibited findings of congenital Heinz\u2010body hemolytic anemia accompanied by cyanosis. Two of the affected family members have also developed severe pulmonary hypertension, with a fatal outcome in one of them. Blood from the affected individuals showed decreased oxygen affinity and contained elevated levels of methemoglobin. An unstable hemoglobin fraction underwent rapid precipitation following exposure of the red cell lysates to isopropyl alcohol or heat. This hemoglobin contained a newly identified abnormal \u03b2 chain with an amino acid substitution at the same position as that of Hb Hammersmith and Hb Bucuresti\u2010Louisville.<\/jats:p>","DOI":"10.1002\/ajh.2830320108","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:42:15Z","timestamp":1172058135000},"page":"36-41","source":"Crossref","is-referenced-by-count":18,"title":["Hb Warsaw (\u03b242 Phe \u2192 Val): An unstable hemoglobin with decreased oxygen affinity. I. Hematologic and clinical expression"],"prefix":"10.1002","volume":"32","author":[{"given":"George R.","family":"Honig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret C.","family":"Telfer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barnett B.","family":"Rosenblum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loyda N.","family":"Vida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104406"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197607152950302"},{"key":"e_1_2_1_4_2","first-page":"48","article-title":"Methemoglobinemia in man","volume":"4","author":"Jaff\u00e9 ER","year":"1964","journal-title":"Progr Hematol"},{"key":"e_1_2_1_5_2","volume-title":"Diagnostic Laboratory Hematology","author":"Cartwright GE","year":"1963"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.3.1475"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/03630267609031020"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1182\/blood.V55.1.131.131","article-title":"Hemoglobin Nigeria (\u03b1\u201081 Ser \u2192 Cys): A new variant associated with \u03b1\u2010thalassemia","volume":"55","author":"Honig GR","year":"1980","journal-title":"Blood"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0021-9258(18)73873-8","article-title":"Micro determination of oxyhemoglobin, methemoglobin and sulfhemoglobin in a single sample of blood","volume":"126","author":"Evelyn KA","year":"1938","journal-title":"J Biol Chem"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1972.tb07096.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(66)80052-9"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2795(80)90138-5"},{"key":"e_1_2_1_13_2","first-page":"860","article-title":"A silent, neutral substitution detected by reverse\u2010phase high\u2010performance liquid chromatography","volume":"221","author":"Strahler JR","year":"1983","journal-title":"Hemoglobin Beirut Science"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111382"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/03630267809007076"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(67)90141-6"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1182\/blood.V51.5.971.971","article-title":"Isoelectric focusing of human hemoglobin: Its application to screening, to the characterization of 70 variants, and to the study of modified fractions of normal hemoglobins","volume":"51","author":"Basset P","year":"1978","journal-title":"Blood"},{"key":"e_1_2_1_18_2","first-page":"68","volume-title":"Hemoglobin: Structure, Function, Evolution, and Pathology","author":"Dickerson RE","year":"1983"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/216663a0"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2795(71)90051-1"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106738"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(73)80383-9"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1975.tb00533.x"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830320108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830320108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T05:00:15Z","timestamp":1697950815000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830320108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,9]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1989,9]]}},"alternative-id":["10.1002\/ajh.2830320108"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830320108","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,9]]}}}