{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T01:59:17Z","timestamp":1744163957478},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":6096,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1989,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>National AIDS surveillance suggests that approximately 3.5% of all hemophilic patients in the United States have developed AIDS as of February 1988; however, the cumulative incidence of AIDS among seropositive patients at individual hemophilia treatment centers (HTCs) has been reported to be as high as 12%. The purpose of this study was to examine the reported excess risk of AIDS at selected HTCs. Between July 13 and November 6, 1987, we reviewed medical charts from the 598 hemophilia A and hemophilia B patients receiving comprehensive care as of 1980 at six U.S. hemophilia treatment centers (three identified as low AIDS risk and three identified as high AIDS risk using national hemophilia\u2010associated AIDS surveillance data). The risk of AIDS among all patients was 8% and among seropositive patients was 18%. At the individual HTCs, the risk ranged from 0% to 14% among all patients and 0% to 25% among seropositive patients. Overall incidence rates were higher than those derived from national surveillance data because national estimates include all hemophilic patients (regardless of severity) whereas this study included only patients receiving comprehensive care (who are more likely to be severely affected by their coagulation disorder and receive concentrated clotting factors). The higher incidence of AIDS in the high\u2010risk centers was attributable to the older age of the patients in these HTCs, a factor previously associated with an increased risk of AIDS in seropositive patients. These findings do not support geographic variability in the incidence of AIDS and emphasize the importance of patient characteristics when comparing the incidence of hemophilia\u2010associated AIDS between populations.<\/jats:p>","DOI":"10.1002\/ajh.2830320304","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:57:56Z","timestamp":1172059076000},"page":"178-183","source":"Crossref","is-referenced-by-count":10,"title":["Geographic variability of hemophilia\u2010associated aids in the United States: Effect of population characteristics"],"prefix":"10.1002","volume":"32","author":[{"given":"Jeanette K.","family":"Stehr\u2010Green","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine M.","family":"Jason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce L.","family":"Evatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Study to evaluate the supply\u2010demand relationship for AHF and PTC through 1980","author":"US Department of Health, Education, and Welfare","year":"1977"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.253.23.3409"},{"key":"e_1_2_1_4_2","unstructured":"JasonJM HolmanRC KennedyMS EvattBL:Longitudinal assessment of persons with hemophilia exposed to HTLV\u2010III\/LAV. Program and Abstracts of the 26th Interscience Conference on Antimicrobial Agents and Chemotherapy. New Orleans Louisiana 97 1986(abstr)."},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1182\/blood.V67.3.592.592","article-title":"AIDS retrovirus antibodies in hemophiliacs treated with factor VIII or factor IX concentrates, cryoprecipitates, or fresh frozen plasma: Prevalence, seroconversion rate, and clinical correlations","volume":"67","author":"Ragni MV","year":"1986","journal-title":"Blood"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1182\/blood.V65.2.492.492","article-title":"Antibodies reactive with human T cell leukemia viruses in the serum of hemophiliacs receiving factor VIII concentrate","volume":"65","author":"Goedert JJ","year":"1985","journal-title":"Blood"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90704-7"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1182\/blood.V66.3.718.718","article-title":"Lymphadenopathy\u2010associated virus antibodies in T cells in hemophiliacs treated with cryoprecipitate or concentrate","volume":"66","author":"Gjerset GF","year":"1985","journal-title":"Blood"},{"key":"e_1_2_1_9_2","first-page":"477","article-title":"Prevalence of HTLV\u2010III antibody among New Mexico residents with hemophilia","volume":"145","author":"Waskin H","year":"1986","journal-title":"West J Med"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1182\/blood.V70.4.1208.1208","article-title":"Geographic differences in hemophilia\u2010associated AIDS incidence in Pennsylvania","volume":"70","author":"Pennsylvania AIDS Surveillance Study Group","year":"1987","journal-title":"Blood"},{"key":"e_1_2_1_11_2","first-page":"373","article-title":"Revision of the case definition of acquired immunodeficiency syndrome for national reporting\u2014United States","volume":"34","author":"CDC","year":"1985","journal-title":"MMWR"},{"issue":"1","key":"e_1_2_1_12_2","first-page":"3S","article-title":"Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome","volume":"36","author":"CDC","year":"1987","journal-title":"MMWR"},{"key":"e_1_2_1_13_2","first-page":"669","article-title":"Surveillance of hemophilia\u2010associated acquired immunodeficiency syndrome","volume":"35","author":"CDC","year":"1986","journal-title":"MMWR"},{"key":"e_1_2_1_14_2","volume-title":"Nonparametrics\u2014Statistical Methods Based on Ranks","author":"Lehman EL","year":"1980"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-2927-3"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-1-1"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2418502"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830320304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830320304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T18:59:25Z","timestamp":1698001165000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830320304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,11]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1989,11]]}},"alternative-id":["10.1002\/ajh.2830320304"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830320304","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,11]]}}}