{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:03:18Z","timestamp":1762160598263},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":6035,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Essential thrombocythemia (ET) is a myeloproliferative disorder characterized by isolated overproduction of platelets, thrombohemorrhagic complications, and a median age of 50\u201360. When it occurs in younger patients, the incidence of complications has been reported to be quite low, with a good long\u2010term prognosis. We report a retrospective review of 13 patients with ET between the ages of 22 and 35 in which 11 were symptomatic at diagnosis, with only one remaining asymptomatic during follow\u2010up. Three patients presented with potentially life\u2010threatening complications (two myocardial infarctions, one stroke), although no deaths were observed. The majority of the nonlife\u2010threatening complications were vaso\u2010occlusive in nature, including erythromelalgia and transient neurologic symptoms. We conclude that ET in young adults is not always a benign disease and that potentially life\u2010threatening complications are not rare. The optimum approach to treatment in this or any other age group remains uncertain.<\/jats:p>","DOI":"10.1002\/ajh.2830330106","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:56:22Z","timestamp":1172058982000},"page":"27-31","source":"Crossref","is-referenced-by-count":54,"title":["Clinical manifestations of essential thrombocythemia in young adults"],"prefix":"10.1002","volume":"33","author":[{"given":"Frederick E.","family":"Millard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine S.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin J.","family":"Edelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Kosty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George A.","family":"Luiken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory G.","family":"Marino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"218","volume-title":"Hematology","author":"Silverstein MN","year":"1983"},{"key":"e_1_2_1_3_2","first-page":"578","article-title":"Primary thrombocythemia in the young patient","volume":"53","author":"Hoagland HC","year":"1978","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1982.tb01900.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19861201)58:11<2440::AID-CNCR2820581115>3.0.CO;2-Y"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880615)61:12<2487::AID-CNCR2820611217>3.0.CO;2-T"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1093\/ajcp\/84.2.180","article-title":"Acute thrombotic complications of myeloproliferative disorders in young adults","volume":"84","author":"Davis RB","year":"1985","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6402.1344"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.2.218"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-99-4-513"},{"key":"e_1_2_1_11_2","first-page":"386","article-title":"Thrombocythaemia and recurrent late abortions: Normal outcome of pregnancies after antiaggregatory treatment","volume":"93","author":"Snethlage W","year":"1986","journal-title":"Br J Obstet Gynecol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830250316"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90507-8"},{"key":"e_1_2_1_14_2","first-page":"501","article-title":"Essential thrombocythemia in pregnancy","volume":"71","author":"Jones EC","year":"1988","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1989.tb01215.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880315)61:6<1207::AID-CNCR2820610625>3.0.CO;2-4"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-1-161"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V64.1.1.1","article-title":"Bleeding and thrombosis in the myeloproliferative syndromes","volume":"64","author":"Shafer AI","year":"1984","journal-title":"Blood"},{"key":"e_1_2_1_19_2","first-page":"218a","article-title":"Leukemic transformation in polycythemia vera: Analysis of risk factors","volume":"72","author":"Nand S","year":"1988","journal-title":"Blood"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90005-0"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198805193182002"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(83)90213-2"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830330106","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830330106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T18:04:07Z","timestamp":1697997847000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830330106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,1]]}},"alternative-id":["10.1002\/ajh.2830330106"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830330106","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,1]]}}}