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When the patients were divided into two groups depending on the expression of a mature antigen of T cell lineage, CD3, two with CD3 + phenotype had a stable disease, whereas three of the four patients with CD3\u2010 phenotype had marked hepatosplenomegaly and a highly aggressive disease. Chromosomal abnormalities were detected in four of six patients, indicating a clonal proliferation of large granular lymphocytes in individual patients. In particular, chromosomal abnormalities were found in three of the four patients with CD3\u2010 LDGL. all of which had a germ\u2010line configuration of the T cell receptor beta\u2010chain gene. Thus, the chromosomal abnormalities provide definitive evidence for the clonal origin of the expanded cells in the CD3\u2010LDGL.<\/jats:p>","DOI":"10.1002\/ajh.2830330107","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:56:22Z","timestamp":1172058982000},"page":"32-38","source":"Crossref","is-referenced-by-count":28,"title":["Chromosomal abnormalities define clonal proliferation in CD3\u2010 large granular lymphocyte 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