{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T04:47:14Z","timestamp":1698382034332},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":6035,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 33 year old woman with severe thrombocytopenic purpura complicated by typical lupus anticoagulant developed repeated spontaneous abortion, deep venous thrombosis, and cerebral thrombosis. The platelet count fluctuated from 4,000 to 400,000\/mm<jats:sup>3<\/jats:sup> during the 13 year clinical course. The physical and laboratory findings at the time of severe thrombocytopenic purpure were compatible with the criteria of idiopathic thrombocytopenic purpura except for positive lupus anticoagulant. Both immunosuppressive therapy with prednisolone and antithrombotic therapy with warfarin and aspirin were necessary for the control of bleeding and venous and arterial thrombosis.<\/jats:p>","DOI":"10.1002\/ajh.2830330116","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:56:22Z","timestamp":1172058982000},"page":"75-77","source":"Crossref","is-referenced-by-count":3,"title":["Thrombocytopenic purpura in a patient with lupus anticoagulant: Requirement of both immunosuppressive and antithrombotic therapies"],"prefix":"10.1002","volume":"33","author":[{"given":"Yoshihito","family":"Iwahara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Niiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Yamato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lsao","family":"Miyoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"621","article-title":"A hemorrhagic disorder caused by circulating anticoagulant in patients with disseminated lupus erythematosus","volume":"31","author":"Conley CL","year":"1952","journal-title":"J Clin Invest"},{"key":"e_1_2_1_3_2","first-page":"416","article-title":"Thrombosis in systemic lupus erythematosus despite circulating anticoagulants","volume":"62","author":"Bowie WEJ","year":"1963","journal-title":"J Clin Invest"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1975.tb04897.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830190308"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1985.tb02989.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1182\/blood.V48.4.499.499","article-title":"A clinical study of the lupus anticoagulant","volume":"48","author":"Schleider MA","year":"1976","journal-title":"Blood"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1978.tb03648.x"},{"key":"e_1_2_1_9_2","first-page":"899","article-title":"The property of lupus anticoagulant","volume":"26","author":"Ikeda Y","year":"1985","journal-title":"Rinsyo Ketsueki (In Japanese)"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92087-0"},{"key":"e_1_2_1_11_2","first-page":"486","article-title":"The anticardiolipin syndrome","volume":"13","author":"Hughes GRV","year":"1986","journal-title":"J Rheumatol"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830330116","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830330116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T18:04:46Z","timestamp":1697997886000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830330116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,1]]}},"alternative-id":["10.1002\/ajh.2830330116"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830330116","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,1]]}}}