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The coexistence of the two pathologies is probably also responsible for the observed changes in spectrin: the appearance of an extra spectrin band between tetramers and dimers on denaturing gel electrophoresis and the metabolic\u2010dependent reduction in spectrin amount. It is assumed that the instability of the skeletal network that results from the HE pathology caused increased exposure of the spectrin molecule to oxidative damage that usually occurs in thalassernic red cells. The products of such oxidation may have led to abnormal spectrin associations which finally resulted in the above changes.<\/jats:p>","DOI":"10.1002\/ajh.2830330209","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:56:01Z","timestamp":1172058961000},"page":"123-127","source":"Crossref","is-referenced-by-count":3,"title":["Spectrin modifications in a heterozygous case of both hereditary elliptocytosis and \u03b2\u2010thalassemia"],"prefix":"10.1002","volume":"33","author":[{"given":"Sara","family":"Streichman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethy","family":"Herz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilana","family":"Tatarsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0308-2261(21)00462-8","article-title":"Hereditary elliptocytosis and related disorders","volume":"14","author":"Palek J","year":"1985","journal-title":"Clin Haematol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/285586a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(63)90042-0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(88)90035-1"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1983.tb02085.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1982.22482251202.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.5.4.298"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000208580"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0308-2261(21)00467-7","article-title":"Erythrocyte membrane alterations in \u03b2\u2010thalassemia","volume":"14","author":"Rachmilewitz EA","year":"1985","journal-title":"Clin Haematol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"4620","DOI":"10.1016\/S0021-9258(17)38547-2","article-title":"The effect of mild diamide oxidation on the structure and function of human erythrocyte spectrin","volume":"261","author":"Becker PS","year":"1986","journal-title":"J Biol Chem"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830330209","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830330209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T17:32:38Z","timestamp":1697995958000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830330209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,2]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,2]]}},"alternative-id":["10.1002\/ajh.2830330209"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830330209","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,2]]}}}