{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T21:43:50Z","timestamp":1698097430219},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":5976,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1990,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In an attempt to stimulate granulopoiesis, we administered recombinant human granulocyte\u2010macrophage colony\u2010stimulating factor (GM\u2010CSF) to 11 patients with lymphoprolif\u2010erative disorders. Ten patients had neutropenia, six of whom had severe neutropenia (&lt;500 neutrophils), including two with agranulocytosis. GM\u2010CSF (60\u2010250 \u03bcg\/m<jats:sup>2<\/jats:sup>\/day) was administered by continuous intravenous infusion daily for 14 days at 2\u2010week intervals. Significant increases in white blood cell counts (1.3\u2010 to 11.7\u2010fold) and neutrophils (1.7\u2010 to more than 29\u2010fold) were seen in 10 of 11 patients, including one patient with agranulocytosis. Eosinophils (3.9\u2010 to &gt; 65\u2010fold) and monocytes (1.3\u2010 to &gt;5\u2010fold) increased as well. In contrast, no significant increases were seen in total lymphocytes or in different phenotypic subsets of lymphocytes during treatment. The overall proportion of myeloid and lymphoid elements in bone marrow remained stable. These results indicate that GM\u2010CSF is effective in stimulating myelopoiesis in neutropenic states associated with lymphopro\u2010liferative disorders. Further studies will be necessary to determine whether the correction of neutropenia ultimately translates into clinical benefit.<\/jats:p>","DOI":"10.1002\/ajh.2830330307","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:54:24Z","timestamp":1172058864000},"page":"189-197","source":"Crossref","is-referenced-by-count":12,"title":["Stimulation of myelopoiesis in chronic lymphocytic leukemia and in other lymphoproliferative disorders by recombinant human granulocyte\u2010macrophage colony\u2010stimulating factor"],"prefix":"10.1002","volume":"33","author":[{"given":"Saroj","family":"Vadhan\u2010Raj","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William S.","family":"Velasquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J.","family":"Butler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Lemaistre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Lepe\u2010Zuniga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Keating","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles A.","family":"Koller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan U.","family":"Gutterman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"11","article-title":"The treatment of indolent lymphomas: Watchful waiting versus aggressive combined modality treatment","volume":"25","author":"Young RC","year":"1988","journal-title":"Scmin Hematol"},{"key":"e_1_2_1_3_2","first-page":"17","article-title":"Southwest oncology group clinical trials for intermediate\u2010 and high\u2010grade non\u2010Hodgkin's lymphomas","volume":"2","author":"Miller TP","year":"1988","journal-title":"Semin Hematol"},{"key":"e_1_2_1_4_2","first-page":"211","article-title":"Fludarabine phosphate: A new agent with major activity in low grade lymphoma (abstract)","volume":"29","author":"Redman J","year":"1988","journal-title":"Proc Am Assoc Cancer Res"},{"key":"e_1_2_1_5_2","first-page":"223","article-title":"Fludarabine monophosphate in chronic lymphocytic leukemia (abstract)","volume":"68","author":"Grever MR","year":"1986","journal-title":"Proceedings of the Amer ican Society of Hematology.\u201d Blood"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(66)90105-7"},{"key":"e_1_2_1_7_2","first-page":"1946","article-title":"Infection and chronic lymphocytic leukemia","volume":"62","author":"Aroesty JM","year":"1962","journal-title":"NY State J Med"},{"key":"e_1_2_1_8_2","first-page":"278","article-title":"Specific inhibitory activity against granulocyte\u2010progenitor cells produced by non\u2010T lymphocytes from patients with neutropenia","volume":"8","author":"Broxmeyer HE","year":"1980","journal-title":"Exp Hematol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1182\/blood.V64.6.1146.1146","article-title":"T\u2010\u03b3\u2010lymphoproliferative disease and related disorders in humans and experimental animals: A review of the clinical, cellular, and functional characteristics","volume":"64","author":"Reynolds CW","year":"1984","journal-title":"Blood"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(84)90077-4"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1987.tb10966.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000207372"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3296190"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1182\/blood.V69.1.43.43","article-title":"Purification and properties of bacterially synthesized human granulocyte\u2010macrophage colony\u2010stimulating factor","volume":"69","author":"Burgess AW","year":"1987","journal-title":"Blood"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/314361a0"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.18.6250"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3923623"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198709033171003"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712173172501"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1182\/blood.V72.1.134.134","article-title":"Stimulation of hematopoiesis in patients with bone marrow failure and in patients with malignancy by recombinant human granulocyte\u2010macrophage colony\u2010stimulating factor","volume":"72","author":"Vadhan\u2010Raj S","year":"1988","journal-title":"Blood"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198812223192503"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.2.705.705"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198804073181401"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.164.1.251"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1985.tb03721.x"},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1200\/JCO.1989.7.2.159","article-title":"Hematopoietic responses in patients with advanced malignancy treated with recombinant human granulocyte\u2010macrophage colony\u2010stimulating factor","volume":"7","author":"Herrmann F","year":"1989","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V73.3.849.849"},{"key":"e_1_2_1_28_2","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.4049\/jimmunol.138.11.4042","article-title":"Establishment and characterization of an undifferentiated human T leukemia cell line which requires granulocyte\u2010macrophage colony stimulatory factor for growth","volume":"138","author":"Valtieri M","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_1_29_2","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.4049\/jimmunol.138.12.4288","article-title":"Growth of an interleukin 2\/interleukin 4\u2010dependent T cell line induced by granulocyte\u2010macrophage colony\u2010stimulating factor (GM\u2010CSF)","volume":"138","author":"Kupper T","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_1_30_2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1182\/blood.V70.1.192.192","article-title":"Growth factor requirements of childhood acute leukemia: Establishment of GM\u2010CSF\u2010dependent cell lines","volume":"70","author":"Lange B","year":"1987","journal-title":"Blood"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.1.19.bloodjournal74119"},{"key":"e_1_2_1_32_2","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1200\/JCO.1985.3.11.1451","article-title":"Bone marrow transplantation as salvage therapy in advanced Hodgkin's disease: Allogenic or autologous (editorial)","volume":"3","author":"Canellos GP","year":"1985","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.5530040711"},{"key":"e_1_2_1_34_2","first-page":"291","article-title":"Mechanisms of infection in chronic lymphocytic leukemia","volume":"24","author":"Chapel HM","year":"1987","journal-title":"Semin Hematol"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197911000-00046"},{"key":"e_1_2_1_36_2","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1001\/archinte.1973.03650100076014","article-title":"Infections complicating multiple mycloma and chronic lymphocytic leukemia","volume":"132","author":"Twomey JJ","year":"1973","journal-title":"Arch Intern Med"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198611000-00012"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830330307","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830330307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T18:16:02Z","timestamp":1697998562000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830330307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,3]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,3]]}},"alternative-id":["10.1002\/ajh.2830330307"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830330307","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,3]]}}}