{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T02:56:10Z","timestamp":1770432970355,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":5976,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1990,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To clarify the idea that an alteration of the transferrin receptor (TF\u2010R) gene, localized to 3q26, may be of pathogenetic significance in hematological disorders with 3q anomaly, we studied the TF\u2010R systems of erythroblasts from both functional and genetic aspects. The patient described here had refractory anemia with an excess of blasts (RAEB), with paracentric inversion, inv(3)(q21q26). The patient had the characteristic findings of mi\u2010 cromegakaryocytosis and thrombocytosis, with giant platelets. There was no functional abnormality of TF\u2010R as far as number of binding sites, affinity, molecular weight, or recycling kinetics were concerned. Furthermore, we could not recognize any rearrangement of the TF\u2010R gene with Southern blot analysis. These data suggest that TF\u2010R is not involved in the pathogenesis of leukemogenesis and thrombocytosis of the disease.<\/jats:p>","DOI":"10.1002\/ajh.2830330311","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:54:24Z","timestamp":1172058864000},"page":"215-219","source":"Crossref","is-referenced-by-count":9,"title":["The transferrin receptor system is not involved in the pathogenesis of hematological disorders with 3q 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