{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:54:30Z","timestamp":1760853270095},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":5945,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1990,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hematological abnormalities are common in patients with AIDS or AIDS\u2010related complex. We studied cytological characteristics in peripheral blood and bone marrow samples of 33 hemophilic patients with HIV Infection and in six HIV negatives. The HIV\u2010positive patients presented leukopenia (60.6%), thrombocytopenia (69.9%), and anemia (57.5%). Bone marrow showed abnormalities of maturation in one or more cell lines similar to those described in other HIV\u2010infected groups of patients. These findings were more prominent in megacaryocytes and granulocytic series. Lymphocytosis, plasmocytosis, and increased hemophagocytosis were also common. These alterations do not appear in HIV\u2010negative patients and seem related to a direct effect of HIV on bone marrow cells or to alterations in T\u2010cell regulatory functions.<\/jats:p>","DOI":"10.1002\/ajh.2830330403","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:55:46Z","timestamp":1172058946000},"page":"230-233","source":"Crossref","is-referenced-by-count":12,"title":["Hematological abnormalities in hemophilic patients with human immunodeficiency virus infection"],"prefix":"10.1002","volume":"33","author":[{"given":"Jose L.","family":"Bello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Burgaleta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Magallon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Herruzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose M.","family":"Villar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.250.22.3084"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90695-8"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-101-6-877_1"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/84.2.144"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/86.6.788"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/87.5.584"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1987.00261.x-i1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1987.tb01307.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-105-2-234"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198409063111004"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/ajcp\/88.1.121b","article-title":"Granulopoietic precursors in hemophiliac patients infected by HTLV III\/LAV","volume":"88","author":"Burgaleta C","year":"1987","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/326200a0"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1182\/blood.V64.1.105.105","article-title":"T lymphocyte colony assay in hemophiliacs","volume":"64","author":"Ragni MV","year":"1984","journal-title":"Blood"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1182\/blood.V67.4.1063.1063","article-title":"Abnormal in vitro proliferation and differentiation of T colony\u2010forming cells in patients with lymphadenopathy syndrome","volume":"67","author":"Lunardi\u2010Iskandar Y","year":"1986","journal-title":"Blood"},{"key":"e_1_2_1_16_2","first-page":"278","article-title":"Les lymphomes et le SIDA","volume":"6","author":"Raphael M","year":"1986","journal-title":"Ann Pathol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1093\/ajcp\/88.3.348","article-title":"Paraproteinemias in homosexual men with HIV infection. 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