{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T13:10:04Z","timestamp":1698066604072},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":5915,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The indolent follicular and diffuse lymphomas are neoplasms of B\u2010cell origin. In several other B\u2010cell neoplastic disorders, including multiple myeloma, hairy cell leukemia, and chronic lymphocytic leukemia, the light chain isotype of the surface immunoglobulin has been reported to have prognostic significance. Patients with tumors expressing \u03bb light chains usually fare more poorly than those with k light chain\u2010bearing tumors. We analyzed the clinical data and immunologic phenotype of 101 patients with indolent lymphoma. Eighty\u2010nine of the 101 patients demonstrated surface immunoglobulin of only one light chain type (k\u201047, \u03bb\u201042). Patients in both groups were matched for known prognostic factors. There were no significant differences in disease\u2010free survival or overall survival between the two groups or within histologic subtypes. These results indicate that the immunologic light chain phenotype in indolent lymphoma, unlike other B\u2010cell neoplasms, is not a prognostic indicator of survival.<\/jats:p>","DOI":"10.1002\/ajh.2830340105","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:53:42Z","timestamp":1172058822000},"page":"15-20","source":"Crossref","is-referenced-by-count":3,"title":["Surface light chain phenotype in indolent lymphomas: Lack of prognostic significance"],"prefix":"10.1002","volume":"34","author":[{"given":"Louis A.","family":"Vandermolen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia L.","family":"Duffey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Cossman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine S.","family":"Jaffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan L.","family":"Longo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110770"},{"key":"e_1_2_1_3_2","first-page":"953","article-title":"Functional markers: A new perspective on malignant lymphomas","volume":"61","author":"Jaffe ES","year":"1977","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/jnci\/54.1.11","article-title":"Malignant lymphomas of follicular center cell origin in man. 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