{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T20:38:59Z","timestamp":1760819939680},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":5701,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1990,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 14\u2010year\u2010old boy with fatal varicella zoster virus\u2010associated hemophagocytic syndrome (VAHS) was treated with recombinant human granulocyte colony\u2010stimulating factor (G\u2010CSF) based on the finding that the patient had severe neutropenia and possible bacterial superinfection. Support for the G\u2010CSF therapy in VAHS is provided by the recent reports that G\u2010CSF is relatively specific for the granulocyte lineage; it would not activate mature monocyte\/macrophage\/histiocyte lineage in VAHS, where the most striking morphologic feature is histiocytic hyperplasia with hemophagocytosis. He responded well to G\u2010CSF with an elevation of neutrophil counts. There were no effects on other blood cells. The result indicates that G\u2010CSF is useful to increase granulocyte production in severe neutropenia, even in the setting of fatal VAHS.<\/jats:p>","DOI":"10.1002\/ajh.2830350409","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T12:10:34Z","timestamp":1172059834000},"page":"266-268","source":"Crossref","is-referenced-by-count":16,"title":["G\u2010CSF enhanced granulocyte production in a child with severe neutropenia in the setting of fatal virus\u2010associated hemophagocytic syndrome"],"prefix":"10.1002","volume":"35","author":[{"given":"Eiichi","family":"Azuma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutada","family":"Tabata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeo","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Komada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin\u2010Ichiro","family":"Atsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"GillioAP BonillaMR PotterGK:Effects of recombinant human granulocyte\u2013colony stimulating factor on hematopoietic reconstitution after autologous bone marrow transplantation in primates. 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