{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:56:31Z","timestamp":1772898991118,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":5580,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1991,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a case of a patient who developed a fatal adult respiratory distress syndrome (ARDS) during treatment with rh granulocyte\u2010macrophage colony stimulating factor (rhGM\u2010CSF) (250 mcg\/m<jats:sup>2<\/jats:sup>\/day s.c.) and low\u2010dose cytosine\u2010arabinoside (Ara\u2010C) (20 mg\/m<jats:sup>2<\/jats:sup>\/day s.c.). Several mechanisms which might explain the lung tissue damage in this patient were explored. GM\u2010CSF increased the expression of the glycoproteins CD11<jats:sup>B<\/jats:sup> and CD18 on the surface of his neutrophils, which may have increased the adhesiveness of neutrophils to the pulmonary endothelium. In addition, GM\u2010CSF primed the neutrophils of the patient to an enhanced release of superoxide anions. Both findings may at least partially explain why GM\u2010CSF exerted a deleterious action on the pulmonary endothelial integrity in this patient. Other factors, such as increased platelet\u2010activating factor production by the neutrophils or tumor necrosis factor\u2010mediated mechanisms, may also have played a role. ARDS as a complication of low\u2010dose Ara\u2010C seems less plausible.<\/jats:p>","DOI":"10.1002\/ajh.2830360413","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T12:08:38Z","timestamp":1172059718000},"page":"285-287","source":"Crossref","is-referenced-by-count":38,"title":["Treatment with granulocyte\u2010macrophage colony stimulating factor and the adult respiratory distress syndrome"],"prefix":"10.1002","volume":"36","author":[{"given":"Gregor","family":"Verhoef","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Boogaerts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3296190"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-110-5-357"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1983.tb01241.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1989.tb04287.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1182\/blood.V72.4.1368.1368","article-title":"Production of interleukin\u20131\u03b1, interleukin\u20131\u03b2 and tumor necrosis factor by human mononuclear cells stimulated with granulocyte\u2013macrophage colony\u2013stimulating factor","volume":"72","author":"Sisson DS","year":"1988","journal-title":"Blood"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1003519"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1182\/blood.V69.1.18.18","article-title":"Human GM\u2013CSF primes neutrophils for enhanced oxidative metabolism in response to the major physiological chemoattractants","volume":"69","author":"Weisbart RH","year":"1987","journal-title":"Blood"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1986.26186124040.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1990.tb04345.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(81)90759-2"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830360413","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830360413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T02:01:34Z","timestamp":1698026494000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830360413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,4]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1991,4]]}},"alternative-id":["10.1002\/ajh.2830360413"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830360413","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,4]]}}}