{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:16:48Z","timestamp":1773296208171,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":5519,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1991,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the possibility that persons with sickle cell trait who reside chronically at moderately high altitude might develop impaired splenic reticuloendothelial function. Seventeen healthy young black men with sickle trait who had lived at \u2a7e 1,609 m for \u2a7e 10 years participated in the study along with 25 matched control subjects with normal hemoglobin. Splenic function was assessed by radionuclide liver\u2010spleen scanning and by red cell pit counts. No evidence of impaired splenic function was found in the sickle trait group. The data suggest that long\u2010term residence at moderately high altitude does not place persons with sickle cell trait at risk for splenic dysfunction.<\/jats:p>","DOI":"10.1002\/ajh.2830370214","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T12:51:20Z","timestamp":1172062280000},"page":"130-132","source":"Crossref","is-referenced-by-count":6,"title":["Splenic function in persons with sickle cell trait at moderately high altitude"],"prefix":"10.1002","volume":"37","author":[{"given":"Rachelle","family":"Nuss","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela J.","family":"Feyerabend","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James L.","family":"Lear","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Lane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195409092511102"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1001\/jama.1985.03350390093033","article-title":"Splenic syndrome at mountain altitudes in sickle cell trait: Its occurrence in nonblack persons","volume":"253","author":"Lane PA","year":"1985","journal-title":"JAMA"},{"key":"e_1_2_1_4_2","first-page":"149","article-title":"Simple computer quantitation of spleen\u2010to\u2010liver ratios in the diagnosis of hepatocellular disease","volume":"20","author":"Wasnich R","year":"1979","journal-title":"J Nucl Med"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1182\/blood.V47.2.183.183","article-title":"A new method for studying splenic reticuloendothelial dysfunction in sickle cell disease patients and its clinical application: A brief report","volume":"47","author":"Casper JT","year":"1976","journal-title":"Blood"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1182\/blood.V53.3.358.358","article-title":"Developmental aspects of splenic function in sickle cell diseases","volume":"53","author":"Pearson HA","year":"1979","journal-title":"Blood"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1542\/peds.76.3.392","article-title":"Developmental pattern of splenic dysfunction in sickle cell disorders","volume":"76","author":"Pearson HA","year":"1985","journal-title":"Pediatrics"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992287901800711"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712173172503"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197409192911213"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830370214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830370214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T05:14:52Z","timestamp":1698038092000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830370214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,6]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,6]]}},"alternative-id":["10.1002\/ajh.2830370214"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830370214","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,6]]}}}