{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T11:07:08Z","timestamp":1770721628145,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":5489,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1991,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CD19+CD5+ lymphocytes constitute a minority of peripheral blood B cells. In view of the importance of these cells in the pathogenesis of the immunoregulation of myeloma, their incidence in another lymphoid organ was determined. CD5+ B cells were studied in 9 spleens from patients with multiple myeloma and in 10 spleens from normal individuals removed secondary to trauma. The total number of CD19+ B cells were increased in myeloma spleens (44.4% \u00b1 12.6%) as compared to normal spleens (20.4% \u00b1 7.4%). Likewise, the percentage of CD19 cells which co\u2010expressed CD5 were increased in myeloma (25.3% \u00b1 12.4%) versus normal (4.4% \u00b1 2.3%) spleen. CD5+ B cells isolated from myeloma spleens, but not normal spleens, inhibit production of immunoglobulin in a pokeweed mitogen driven assay. Thus the spleen appears to be an important source of immunoregulatory B cells in multiple myeloma.<\/jats:p>","DOI":"10.1002\/ajh.2830370306","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T12:50:36Z","timestamp":1172062236000},"page":"163-166","source":"Crossref","is-referenced-by-count":7,"title":["CD5 positive immunoregulatory B cells in spleen populations from multiple myeloma patients"],"prefix":"10.1002","volume":"37","author":[{"given":"Malcolm R.","family":"MacKenzie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Paglieroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Caggiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197510302931801"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110028"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111540"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.4049\/jimmunol.139.1.24","article-title":"Multiple myeloma: An immunologic profile. 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The EA rosette\u2010forming cell is a Leu\u20101 positive immunoregulatory B cell","volume":"139","author":"MacKenrie MR","year":"1987","journal-title":"J Immunol"},{"issue":"2","key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"702","DOI":"10.4049\/jimmunol.118.2.702","article-title":"Suppression of the humoral immune response by plasmacytomas: Mediation by adherent mononuclear cells","volume":"118","author":"Kolb JP","year":"1977","journal-title":"J Immunol"},{"key":"e_1_2_1_7_2","first-page":"87","volume-title":"Clinics in Haematology","author":"Ullrich S","year":"1982"},{"key":"e_1_2_1_8_2","first-page":"282","article-title":"Immunosuppression and infection in myeloma","volume":"8","author":"Jacobson DR","year":"1986","journal-title":"Semin Oncol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108736"},{"issue":"6","key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.4049\/jimmunol.124.6.2563","article-title":"Multiple Myeloma: An Immunologic Profile III. 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