{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T06:10:09Z","timestamp":1698041409167},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":5489,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1991,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A new Epstein\u2010Barr virus nuclear antigen (EBNA)\u2010positive B\u2010cell line, designated BALL\u20102, was spontaneously established from the peripheral blood of a 14\u2010year\u2010old boy with an EBNA\u2010negative B\u2010cell acute lymphoblastic leukemia (B\u2010ALL), L2 in the French\u2010American\u2010British classification. The BALL\u20102 cell line grew in suspension with or without forming clumps of cells. The cultured cells exhibited lymphoid morphology with indented or tabulated nuclei, prominent nucleoli, and relatively abundant cytoplasm. Immunologic and cytogenetic studies showed that the BALL\u20102 cell line expressed the B\u2010cell phenotype, Cplg+, Smlg+, CD19+, CD20+, CD38+, la+, and had chromosome translocation, t(8;14)(q24;q32). The same phenotypic and chromosome markers were present in original leukemia cells. These results indicated that the cell line was derived from the patient's leukemia cells. Unexpectedly, however, BALL\u20102 cells were positive for EBNA and EB virus DMA. Gene analysis of the BALL\u20102 cell line showed biallelic rearrangements in the JH locus. One of the JH rearrangement comigrated with a rearranged c\u2010<jats:italic>myc<\/jats:italic> gene, indicating the translocation had occurred between JH and c\u2010<jats:italic>myc<\/jats:italic> loci. The t(8;14) abnormality is a known chromosome marker of Burkitt lymphoma and L3 type ALL. Our studies revealed that this translocation and <jats:italic>myc<\/jats:italic> gene rearrangement can also be found in L2 type B\u2010ALL.<\/jats:p>","DOI":"10.1002\/ajh.2830370309","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T12:50:36Z","timestamp":1172062236000},"page":"179-185","source":"Crossref","is-referenced-by-count":2,"title":["Establishment of a new Epstein\u2010Barr virus nuclear antigen\u2010positive B\u2010cell line, BALL\u20102, with t(8;14)(q24;q32) chromosome abnormality from B\u2010cell acute lymphoblastic leukemia, L2"],"prefix":"10.1002","volume":"37","author":[{"given":"Ichiro","family":"Kubonishi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Daibata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoki","family":"Yano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Isobe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Kurosawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Nagumo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zen\u2010Ichi","family":"Ogita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko 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