{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:07Z","timestamp":1761058627567},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":5458,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1991,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Drug induced agranulocytosis is an uncommon but potentially fatal complication. In some cases, it may be associated with hypoplasia and depletion of granulocytic precursors in the marrow, leading to prolonged neutropenia. We report on the use of granulocytic\u2010macrophage colony stimulating factor (GM\u2010CSF) in two such cases, at a dose of 10 \u03bcg per kilogram per day subcutaneously. The absolute neutrophil count rose above 500\/mm<jats:sup>3<\/jats:sup> in 3 days in both cases. We believe that GM\u2010CSF expedited the recovery of granulocyte counts in our patients and warrants further study in the management of drug induced neutropenia.<\/jats:p>","DOI":"10.1002\/ajh.2830370411","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T12:49:21Z","timestamp":1172062161000},"page":"267-269","source":"Crossref","is-referenced-by-count":24,"title":["Granulocyte\u2010macrophage colony stimulating factor for the treatment of drug induced agranulocytosis"],"prefix":"10.1002","volume":"37","author":[{"given":"Sucha","family":"Nand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Bayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Prim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Felten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.","family":"Godwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"813","volume-title":"Hematology","author":"Dale DC","year":"1990"},{"key":"e_1_2_1_3_2","first-page":"573","volume-title":"Blood: Textbook of Hematology","author":"Jandl JH","year":"1987"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1985.tb02813.x"},{"key":"e_1_2_1_5_2","first-page":"292","article-title":"Drug induced agranulocytosis","volume":"67","author":"Pisciotta AV","year":"1982","journal-title":"Hematologica (Pavia)"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830160113"},{"key":"e_1_2_1_7_2","first-page":"298","volume-title":"Colony Stimulating Factors and Host Defense","author":"Gasson JC","year":"1989"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198809083191001"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1182\/blood.V73.3.694.694","article-title":"Treatment of refractory aplastic anemia with recombinant human granulocyte macrophage colony stimulating factor","volume":"73","author":"Champlin RE","year":"1988","journal-title":"Blood"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712173172501"},{"key":"e_1_2_1_11_2","first-page":"499","article-title":"Drug\u2010induced inhibition of myeloid colony growth: protective effect of colony stimulating factor","volume":"86","author":"Yunis AA","year":"1975","journal-title":"J Lab Clin Med"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830370411","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830370411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T09:34:43Z","timestamp":1698053683000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830370411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,8]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1991,8]]}},"alternative-id":["10.1002\/ajh.2830370411"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830370411","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,8]]}}}