{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T10:42:38Z","timestamp":1698144158207},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":5458,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1991,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Isolated gastrointestinal (GI) infiltrate is unusual at presentation or relapse of acute myelogenous leukemia (AML). We report a case of acute myelogenous leukemia (FAB\u2010M4) whose isolated relapse presented as a bleeding gastric ulcer. The patient was a 30\u2010year\u2010old male who had been diagnosed to have AML in June 1988. While in third complete remission, he underwent a sibling allogeneic HLA\u2010matched bone marrow transplant. Five months after transplantation, he was readmitted for pneumonia. While in the hospital, he had an episode of upper GI bleeding. The endoscopy revealed a leukemic gastric ulcer, with morphology and immunophenotyping identical to his initial AML. There was no evidence of leukemia in the blood or bone marrow. Although different types of leukemic infiltrates have been recognized at post\u2010mortem examination, our case is unique because AML presenting as an isolated malignant ulcer has not been described previously. We conclude that relapsing AML may present as an isolated gastric ulcer and suggest that any suspicious lesion on upper GI endoscopy should be biopsied after aggressive platelet support.<\/jats:p>","DOI":"10.1002\/ajh.2830370412","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T12:49:21Z","timestamp":1172062161000},"page":"270-273","source":"Crossref","is-referenced-by-count":3,"title":["Isolated relapse of acute myelogenous leukemia presenting as a gastric ulcer"],"prefix":"10.1002","volume":"37","author":[{"given":"Jean","family":"Roy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Vercellotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Fenderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Mulvahill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale","family":"Snover","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Weisdorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1943.00210060038003"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.15.4.305"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-61-6-1084"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1931.00140190053005"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1955)8:1<132::AID-CNCR2820080118>3.0.CO;2-6"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198707000-00015"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1182\/blood.V66.6.1436.1436","article-title":"Restriction fragment length polymorphisms as markers of engraftment in allogeneic marrow transplantation","volume":"66","author":"Blazer BR","year":"1985","journal-title":"Blood"},{"key":"e_1_2_1_9_2","first-page":"572","article-title":"Les localisations digestives des h\u00e9mopathies malignes","volume":"29","author":"Debray J","year":"1958","journal-title":"Le Sang"},{"key":"e_1_2_1_10_2","first-page":"345","article-title":"Acute leukemia: A pathologic study of the causes of death in 157 proved cases","volume":"85","author":"Leach WB","year":"1961","journal-title":"Can Med Assoc J"},{"key":"e_1_2_1_11_2","first-page":"67","article-title":"Gastrointestinal complications in patients with acute and chronic leukemia","volume":"24","author":"Dewar GJ","year":"1981","journal-title":"Can J Surg"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000206836"},{"key":"e_1_2_1_13_2","first-page":"351","article-title":"Leukamische Infiltration der Magenwand bei lymphatischer Leuk\u00e4mie","volume":"59","author":"Steinbrinck W","year":"1938","journal-title":"Folia Haematol (Leipz)"},{"key":"e_1_2_1_14_2","first-page":"21","article-title":"Gastrointestinal involvement in lymphatic leukemia","volume":"35","author":"Pearson B","year":"1943","journal-title":"Arch Pathol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195905282602203"},{"key":"e_1_2_1_16_2","first-page":"833","article-title":"H\u00e9morragie intestinale. Premi\u00e8re manifestation \u010fune leucose aigu\u00eb \u00e0 localisation digestive","volume":"49","author":"Etienne\u2010Martin P","year":"1960","journal-title":"Arch Mal App Digest"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1182\/blood.V22.1.92.92","article-title":"Extensive leukemic infiltration of the gastrointestinal tract during apparent remission in acute leukemia","volume":"22","author":"Everett CR","year":"1963","journal-title":"Blood"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1989.tb06317.x"},{"key":"e_1_2_1_19_2","first-page":"79","article-title":"Granulocytic sarcoma of the intestine as a primary manifestation nine months prior to overt acute myelogenous leukemia","volume":"17","author":"Toki H","year":"1987","journal-title":"Jpn J Clin Oncol"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/ajcp\/68.5.616","article-title":"Preleukemic granulocytic sarcomas of the gastrointestinal tract","volume":"68","author":"Brugo EA","year":"1971","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0300-5089(21)00285-6","article-title":"The gut as a lymphoid organ","volume":"5","author":"Parrot DM","year":"1976","journal-title":"Clin Gastroenterol"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830370412","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830370412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T09:34:50Z","timestamp":1698053690000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830370412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,8]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1991,8]]}},"alternative-id":["10.1002\/ajh.2830370412"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830370412","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,8]]}}}