{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:29:35Z","timestamp":1760016575016},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":5397,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1991,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Severe thrombocytopenia is an uncommon (incidence &lt;1%) but serious complication of infectious mononucleosis. Corticosteroids have been used for therapy with variable responses reported. Five consecutive patients with infectious mononucleosis\u2010related severe thrombocytopenia were treated with intravenous gammaglobulin (IVIG) at a dose of 400 mg\/kg\/day for 2\u20135 days. All patients appear to have had an immunologic or consumptive etiology for their thrombocytopenia as determined by increased marrow megakaryocytes. All patients were initially treated with oral prednisone 1 mg\/kg\/day. Due to the relatively slow response to prednisone (platelet count &gt;20,000\/\u03b3L on the 8th to 13th hospital day) or increased bleeding symptoms, IVIG was initiated. Four of the five patients rapidly developed significant increases in their platelet counts (range 44,000\/\u03b3L to 97,000\/\u03b3L). Two of these responses were sustained and two relapses occurred (while on continued steroid therapy) which again responded to booster doses of IVIG at similar doses. IVIG has been previously shown to be effective in treating patients with idiopathic thrombocytopenia purpura. Historically, patients with infectious mononucleosis\u2010related severe thrombocytopenia often are refractory to corticosteroid therapy and our limited experience suggests that IVIG may also be effective in infectious mononucleosis\u2010related severe thrombocytopenia.<\/jats:p>","DOI":"10.1002\/ajh.2830380210","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T12:48:58Z","timestamp":1172062138000},"page":"124-129","source":"Crossref","is-referenced-by-count":18,"title":["Intravenous gammaglobulin treatment for immune thrombocytopenia associated with infectious mononucleosis"],"prefix":"10.1002","volume":"38","author":[{"given":"Elizabeth M.","family":"Cyran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob M.","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Bloom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1182\/blood.V25.5.817.817","article-title":"Platelet levels in infectious mononucleosis","volume":"25","author":"Carter RL","year":"1964","journal-title":"Blood"},{"key":"e_1_2_1_3_2","first-page":"1905","article-title":"Thrombocytopenic purpura in infectious mononucleosis","volume":"56","author":"Pader E","year":"1956","journal-title":"NY State J Med"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1969.00480110097009"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(63)80301-7"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1961.73040330028011d"},{"key":"e_1_2_1_7_2","first-page":"S124","article-title":"Severe thrombocytopenia in infectious mononucleosis","volume":"74","author":"Mazza JJ","year":"1975","journal-title":"Wis Med J"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-196412000-00011"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(73)90198-8"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1984.tb02169.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1989.tb01247.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(18)30671-3"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","unstructured":"BenjaimS: Infectious mononucleosis with thrombocytopenic purpura.Br Medical J [Clin Res](2) (Nov 22):1151\u20131152 1952.","DOI":"10.1136\/bmj.2.4794.1151-b"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1972.tb04848.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198205273062102"},{"key":"e_1_2_1_16_2","unstructured":"RauchAE ScharfmanWB: Thrombocytopenic purpura and infectious mononucleosis\u2014a possible role for high dose intravenous immunoglobulin.NY State J Med August436\u2013437 1986."},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365548909035687"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.1989.tb00169.x"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830380210","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830380210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T12:01:48Z","timestamp":1698062508000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830380210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,10]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,10]]}},"alternative-id":["10.1002\/ajh.2830380210"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830380210","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,10]]}}}