{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:53:29Z","timestamp":1787507609330,"version":"build-2736575974"},"reference-count":4,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":5397,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1991,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Few chemicals in the environment have been implicated as causes of isolated thrombocytopenia, and the evidence is usually less than convincing because the patients were not rechallenged with the chemical\n                    <jats:italic>in vivo<\/jats:italic>\n                    . In the present paper, a child is reported with the onset of thrombocytopenia in temporal association with environmental exposure to polyurethane. Five years after the initial thrombocytopenia had resolved, an inadvertent\n                    <jats:italic>in vivo<\/jats:italic>\n                    rechallenge with environmental polyurethane resulted in recurrence of the thrombocytopenia. This recurrence, together with the fact that only 1\u20134% of cases of idiopathic thrombocytopenic purpura in children recur, provided strong evidence for a causal role for the polyurethane exposure in this patient's thrombocytopenia. In summary, environmental exposure to polyurethane should be considered in the differential diagnosis of acquired thrombocytopenia in childhood.\n                  <\/jats:p>","DOI":"10.1002\/ajh.2830380215","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T07:48:58Z","timestamp":1172044138000},"page":"145-146","source":"Crossref","is-referenced-by-count":4,"title":["Thrombocytopenia associated with environmental exposure to polyurethane"],"prefix":"10.1002","volume":"38","author":[{"given":"Alan D.","family":"Michelson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1343","volume-title":"Hematology of Infancy and Childhood","author":"Stuart MJ","year":"1987"},{"key":"e_1_2_1_3_2","first-page":"73","volume-title":"Hemorrhagic and Thrombotic Diseases in Childhood and Adolescence","author":"Corrigan JJ","year":"1985"},{"key":"e_1_2_1_4_2","first-page":"387","volume-title":"Platelet Immunobiology. Molecular and Clinical Aspects","author":"Aster RH","year":"1989"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(63)92301-8"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830380215","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830380215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T08:02:17Z","timestamp":1698048137000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830380215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,10]]},"references-count":4,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,10]]}},"alternative-id":["10.1002\/ajh.2830380215"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830380215","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,10]]}}}