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Fourteen of the 17 (82%) cases of acute lymphoblastic leukemia (ALL), and all 15 cases (100%) of B\u2010cell chronic lymphocytic leukemia, who had rearrangement of the Ig gene heavy chain by Southern analysis, were positive by PCR with either one or both pairs of primers. This technique was able to detect leukemic cells at the level of 0.1%. Applying it to study the remission marrow specimens following induction chemotherapy was more useful than morphology alone in predicting early relapse of the leukemia.<\/jats:p>","DOI":"10.1002\/ajh.2830380307","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T12:47:37Z","timestamp":1172062057000},"page":"189-193","source":"Crossref","is-referenced-by-count":15,"title":["Detection of immunoglobulin gene rearrangement in acute and chronic lymphoid leukemias of B\u2010cell lineage by polymerase chain reaction gene amplification"],"prefix":"10.1002","volume":"38","author":[{"given":"Raymond","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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