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However, in patients with TTP and DIC, TM levels decreased significantly after they achieved complete remission. In both TTP and DIC patients, plasma TM levels at onset in those with poor prognosis were higher than that in those with good prognosis. Among DIC patients, the plasma TM level was higher in those with organ failure than in those without, but there were no differences among patients with various underlying diseases associated with DIC. It is speculated that the plasma TM level reflects damage to vascular endothelial cells or organ failure and that it is useful in assessing prognosis for patients with DIC and TTP.<\/jats:p>","DOI":"10.1002\/ajh.2830390106","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T12:46:10Z","timestamp":1172061970000},"page":"20-24","source":"Crossref","is-referenced-by-count":83,"title":["Plasma thrombomodulin as a marker of vascular disorders in thrombotic thrombocytopenic purpura and disseminated intravascular coagulation"],"prefix":"10.1002","volume":"39","author":[{"given":"Hideo","family":"Wada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiaki","family":"Ohiwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigehisa","family":"Tamaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoaki","family":"Tanigawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Shirakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.4.2249"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)68276-1"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.101.2.363"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1093\/oxfordjournals.jbchem.a122523","article-title":"Functionally active thrombomodulin is present human platelets","volume":"104","author":"Suzuki K","year":"1983","journal-title":"J Biochem"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"5532","DOI":"10.1016\/S0021-9258(19)69233-1","article-title":"Functional properties of an endothelial cofactor forthrombin\u2010Catalyzed activation of protein C","volume":"256","author":"Owen WG","year":"1981","journal-title":"J Biol Chem"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00544a001"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)33076-X"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1004414"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"7944","DOI":"10.1016\/S0021-9258(18)34276-5","article-title":"Complex formation between thromation and thrombomodulin inhibits both thrombin\u2010Catalyzed fibrin formation and factor V activation","volume":"257","author":"Esmon CT","year":"1982","journal-title":"J Biol Chem"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"12238","DOI":"10.1016\/S0021-9258(17)44163-9","article-title":"Thrombomodulin blocks the ability of thrombin to activate platelets","volume":"258","author":"Esmon NL","year":"1983","journal-title":"J Biol Chem"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112225"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a123295"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","unstructured":"KodamaS UchijimaE NagaiM MikawataniK HayashiT SuzukiK: One step sandwich enzyme immunoassay from human thrombomodulin using monoclonal antibodies.Clin Chim Acta1990 in press.","DOI":"10.1016\/0009-8981(90)90221-D"},{"key":"e_1_2_1_15_2","first-page":"265","article-title":"Criteria for diagnosis of DIC based on the analysis of clinical and laboratory findings in 345 DIC patients collected by the Research Committee on DIC in Japan","volume":"49","author":"Kobayashi N","year":"1987","journal-title":"Bibl Haematol"},{"key":"e_1_2_1_16_2","first-page":"181","article-title":"Disseminated intravascular coagulation. 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