{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:50:40Z","timestamp":1762113040808},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":5274,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1992,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bleeding times, von Willebrand activities, and platelet retentions were examined before and following d\u2010DAVP in 13 uremic patients. Shortening of the bleeding time from 16.6 \u00b1 2.2 (SEM) to 6.8 \u00b1 0.7 min was seen in six patients. However, bleeding times remained \u00b1 20 min in the remaining seven individuals. The only baseline parameter that correlated with response to d\u2010DAVP was the amount of blood loss (mg\/min) during the bleeding time test. Responders had normal blood loss values averaging 6.2 \u00b1 1.5 mg\/min. By contrast, these values were elevated in 6\/7 of the non\u2010responders and averaged 28.4 \u00b1 5.9 mg\/min (<jats:italic>P<\/jats:italic> = 0.01). Von Willebrand activities increased following d\u2010DAVP in the responders but not in the non\u2010responders. Platelet retention was uniformly low in all patients and improved from 21.0 \u00b1 7.0% to 75.0 \u00b1 7.9% (<jats:italic>P<\/jats:italic> = &lt;0.001) following d\u2010DAVP in responders but not non\u2010responders. To further define the retention abnormality in uremia, the two\u2010stage platelet retention assay was performed prior to d\u2010DAVP. Most of the patients (9\/12) had both first\u2010 and second\u2010phase abnormalities. Therefore, the retention defect in uremia appears to be more complex than that seen in von Willebrand's disease (2nd phase abnormality only). Nevertheless, d\u2010DAVP seems to improve platelet rheology in uremic individuals whose von Willebrand activities increase with d\u2010DAVP.<\/jats:p>","DOI":"10.1002\/ajh.2830390204","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T12:44:40Z","timestamp":1172061880000},"page":"90-95","source":"Crossref","is-referenced-by-count":45,"title":["Desmopressin (d\u2010DAVP) effects on platelet rheology and von willebrand factor activities in uremia"],"prefix":"10.1002","volume":"39","author":[{"given":"Zella R.","family":"Zeigler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Megaludis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald 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