{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T04:54:05Z","timestamp":1698382445898},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":5184,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1992,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A trial of recombinant human granulocyte colony\u2010stimulating factor (rhG\u2010CSF) was attempted in a male with agranulocytosis, infection, and T\u2010gamma lymphoproliferative disease (T\u2010\u03b3\u2010LPD). During five days of rhG\u2010CSF (960 \u03bcg\/day), the absolute neutrophil count (ANC) increased from 0.0 to 4.5 K\/\u03bcI. There were no changes in eosinophil or lymphocyte counts. In addition, there was no toxicity. Bone marrow cytotoxic\/suppressor cells (CD57+\/CD8+) were elevated (21.9%) before and decreased to 10.6% (normal &lt; 12%) following rhG\u2010CSF. By contrast, there was no change in activated T cells (CD3+DR+) or T cell gene rearrangements. These findings suggest rhG\u2010CSF can improve granulopoiesis in T\u2010\u03b3\u2010LPD, possibly by altering T\u2010cell mediated marrow suppression. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830400115","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:03:24Z","timestamp":1172063004000},"page":"66-68","source":"Crossref","is-referenced-by-count":12,"title":["Successful treatment of T\u2010\u03b3 lymphoproliferative disease with human\u2010recombinant granulocyte colony stimulating factor"],"prefix":"10.1002","volume":"40","author":[{"given":"David F.","family":"Lang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. S.","family":"Rosenfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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R.","family":"Zeigler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1182\/blood.V64.6.1146.1146","article-title":"T gamma\u2010lymphoproliferative disease and related disorders in humans and experimental animals: a review of the clinical, cellular, and functional characteristics","volume":"64","author":"Reynolds CW","year":"1984","journal-title":"Blood"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V68.5.1142.1142"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/81.18.1370"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830360219"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1989.tb06291.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1991.tb07987.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1990.tb02550.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110415"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1182\/blood.V74.6.2237.2237","article-title":"Graft failure after T\u2010cell depleted human leukocyte antigen identical marrow transplants for leukemia: II. In vitro analyses of host effector mechanisms","volume":"74","author":"Bordignon C","year":"1989","journal-title":"Blood"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830400115","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830400115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T19:59:54Z","timestamp":1698091194000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830400115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,5]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,5]]}},"alternative-id":["10.1002\/ajh.2830400115"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830400115","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,5]]}}}