{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:26:31Z","timestamp":1786976791780,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":5153,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1992,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In a prospective study on 44 cases of T\u2010cell origin acute lymphoblastic leukemia, 20 patients were found to display an immature immunophenotype (CD7+, CD4\u2010, CD8\u2010, CD1\u2010) and were classified as T\u2010stem cell leukemia (T\u2010SCL). Twenty\u2010four patients expressed CD4 and\/or CD8 antigens on their blast cells, designated T acute lymphoblastic leukemia (T\u2010ALL). The T\u2010SCL subset showed a significantly higher median age, a more frequent incidence of extramedullary leukemia, a morphology L1 in most cases, and a poor response to treatment in terms of either complete remission rate or median survival duration. In addition, significant differences between the two groups were found in evaluating the number of days of blast disappearance from peripheral blood, of CR achievement, and of neutrophils and platelets recovery. We conclude that T\u2010SCL represents a distinct clinical entity, characterized by a poor response to ALL conventional chemotherapy. Alternative therapeutic approaches should be developed for patients suffering from this form of leukemia, to modify its severe prognosis. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830400205","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T08:02:18Z","timestamp":1172044938000},"page":"98-102","source":"Crossref","is-referenced-by-count":15,"title":["Clinical relevance of immunological dissection in T\u2010ALL: A report on 20 cases with stem cell (CD7+, CD4\u2010, CD8\u2010, CD1\u2010) phenotype"],"prefix":"10.1002","volume":"40","author":[{"given":"Felicetto","family":"Ferrara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Cimino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iolanda","family":"Antinolfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"de Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Mele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Mettivier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Fusco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi Del","family":"Vecchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V60.1.1.1"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1182\/blood.V62.5.1108.1108","article-title":"A monoclonal antibody (WT\u20101) for detecting leukemia of T cell precursors","volume":"62","author":"Vodinelich L","year":"1983","journal-title":"Blood"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.3.1588"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1182\/blood.V61.5.830.830","article-title":"Monoclonal anti\u2010body characterization of surface antigens in childhood T cell lymphoid malignancies","volume":"61","author":"Roper M","year":"1983","journal-title":"Blood"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1182\/blood.V60.3.752.752","article-title":"Analysis of T cell differentiation antigens in acute lymphatic leukemia using monoclonal antibodies","volume":"60","author":"Koziner B","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V65.3.730.730"},{"key":"e_1_2_1_8_2","first-page":"227","article-title":"Immunophenotypic characterization and classification of T\u2010acute lymphoblastic leukemia. 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