{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:17:38Z","timestamp":1761675458675},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":5153,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1992,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>By providing some examples of variations in the levels of von Willebrand factor antigen (vWF : Ag), ristocetin cofactor, and Factor VIII during one month, the authors wish to emphasize the difficulty of diagnosing mild forms of von Willebrand's disease (vWD), especially type I. In three of 15 normal female volunteers the vWF : Ag levels, on some sampling occasions, were so low (0.25\u20130.30 IU\/mL, normal &gt; 0.50 IU\/mL) that the diagnosis of vWD type I might be made while on other occasions normal levels were obtained. The coefficients of variation (CV) for vWF : Ag in these three women were 12%, 25%, and 43%. However, CVs of similar magnitude were also observed for \u201cnon\u2010diseased\u201d males and females. The ratio F VIII\/vWF : Ag also varied greatly. In the three women with suspected vWD it was 36%, 15%, and 34%. A representative level for the entire cycle of vWF : Ag and ristocetin cofactor seems to have been obtained in the follicular phase and therefore it is suggested that in order to make the diagnosis of vWD type I, at least in females, blood samples should be taken in this phase. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830400208","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:02:18Z","timestamp":1172062938000},"page":"117-120","source":"Crossref","is-referenced-by-count":40,"title":["On laboratory problems in diagnosing mild von Willebrand's disease"],"prefix":"10.1002","volume":"40","author":[{"given":"M.","family":"Blomb\u00e4ck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Eneroth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Anvret","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","unstructured":"AnvretM Blomb\u00e4ckM LindstedtM S\u00f6derlindE Tapper\u2010PerssonM ThelanderA\u2010C:Genetic and blood coagulation characterization of Swedish families with von Willebrand's disease types I and III. New aspects of heredity. Human Genetics in press 1992.","DOI":"10.1007\/BF00217114"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1648383"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1655470"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365517209102748"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(76)90258-9"},{"key":"e_1_2_1_7_2","unstructured":"BowmanRP HeadDR MarmerDJ BroissotTD:Improved von Willebrand's assay using ristocetin with standardized fixed\u2010frozen platelets. 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