{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:09:41Z","timestamp":1761487781799},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":5153,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1992,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two cases of lymphoma of large granular lymphocytes are reported. The first case expressed natural killer (NK) cell, some T\u2010cell (CD 2, CD 5, CD 8), and HLA\u2010DR antigens, but was negative for other T\u2010cell (CD 3, CD 4, CD 7), T\u2010cell receptor (TCR), B\u2010cell, and myeloid antigens. Germline configuration was demonstrated for TCR, and immunoglobulin heavy and light chain genes. The second case expressed NK cell, some T\u2010cell (CD 3, CD 7, CD 8), and TCR antigens, but was negative for other T\u2010cell (CD 4, CD 5), B\u2010cell, myeloid, and HLA\u2010DR antigens. Rearrangement of TCR \u03b1 and \u03b2 chains were detected. Thus, the findings of case 1 were consistent with true NK cell lineage and case 2 with NK\u2010like T\u2010cell lineage. Our report underscores the heterogeneity of this newly recognized lymphoma, which nevertheless carries a consistently poor prognosis and is probably more prevalent in the Asian population. This study also provides information concerning immunopheno\u2010types of cellular infiltrates in internal organs and cytogenetic abnormalities in this lymphoma; neither has been reported frequently in the literature. The importance of detecting cytoplasmic granules in tissue imprints or electron micrographs for differentiating other T\u2010cell lymphomas is emphasized, and the classification of large granular lymphoproliferative disorders is discussed. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830400211","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:02:18Z","timestamp":1172062938000},"page":"135-145","source":"Crossref","is-referenced-by-count":28,"title":["A study of lymphoma of large granular lymphocytes with modern modalities: Report of two cases and review of the literature"],"prefix":"10.1002","volume":"40","author":[{"given":"Tsieh","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Schulman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Kolitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myron","family":"Susin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Brody","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasad","family":"Koduru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Muuse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiril","family":"Hombal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saul","family":"Teichberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Broome","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)92127-3"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(77)90422-3"},{"key":"e_1_2_1_4_2","first-page":"617","article-title":"Granular lymphocyte proliferative disorders: report of 12 cases and review of the literature","volume":"2","author":"Oshimi K","year":"1988","journal-title":"Leukemia"},{"key":"e_1_2_1_5_2","first-page":"369","volume-title":"Chronic Lymphocytic Leukemia","author":"Foa R","year":"1988"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(18)30499-4"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60845-7"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.12.2421.2421"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840201)53:3<445::AID-CNCR2820530313>3.0.CO;2-D"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19861115)58:10<2224::AID-CNCR2820581011>3.0.CO;2-3"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870715)60:2<183::AID-CNCR2820600211>3.0.CO;2-0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(87)90183-4"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(87)80410-0"},{"key":"e_1_2_1_14_2","first-page":"641","article-title":"A primary immunoblastic T malignant lymphoma of the small bowel, with azurophilic intracytoplasmic granules","volume":"12","author":"Kanavaros P","year":"1988","journal-title":"Am J Surg Pathol"},{"key":"e_1_2_1_15_2","first-page":"43","article-title":"A particular case of large granular lymphocytic lymphoma","volume":"22","author":"Berceanu S","year":"1989","journal-title":"Haematologia"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/ajcp\/93.1.124","article-title":"Aggressive jejunal lymphoma of large granular lymphocytes","volume":"93","author":"Longacre TA","year":"1990","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/29.4.6166661","article-title":"Use of avidin\u2010biotin peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and PAP procedures","volume":"29","author":"Hsu SM","year":"1981","journal-title":"J Histochem Cytochem"},{"key":"e_1_2_1_18_2","volume-title":"Atlas of Cytochemistry and Immunochemistry of Hematologic Neoplasms","author":"Sun T","year":"1985"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/3.9.2303"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(75)80083-0"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(83)90418-9"},{"key":"e_1_2_1_22_2","first-page":"929","article-title":"Molecular analysis of breaks in BCL\u2010I proto\u2010oncogene in B\u2010cell lymphomas with abnormalities of 11q13","volume":"4","author":"Koduru PRK","year":"1989","journal-title":"Oncogene"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830370308"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1982.tb00748.x"},{"key":"e_1_2_1_25_2","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1182\/blood.V60.6.1429.1429","article-title":"Childhood lymphoblastic leukemia with natural killer cell lines retaining activity","volume":"60","author":"Komiyama A","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19841015)54:8<1547::AID-CNCR2820540814>3.0.CO;2-#"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830220404"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V67.4.925.925"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830240113"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1159\/000205617"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(89)90086-6"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830320408"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198103123041106"},{"key":"e_1_2_1_34_2","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1182\/blood.V75.11.2213.2213","article-title":"Hepatosplenic T\u2010cell lymphoma: Sinusal\/sinusoidal localization of malignant cells expressing the T\u2010cell receptor \u03b3\u03b4","volume":"75","author":"Facet JP","year":"1990","journal-title":"Blood"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830350410"},{"key":"e_1_2_1_36_2","first-page":"579","article-title":"Identification and functional characterization of mononuclear cells by flow cytometry","volume":"113","author":"Bray RA","year":"1989","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_37_2","doi-asserted-by":"crossref","first-page":"683","DOI":"10.4049\/jimmunol.139.3.683","article-title":"Acquisition of non\u2010MHC restricted cytotoxic function by IL\u20102 activated thymocytes with an \u201cimmature\u201d antigenic phenotype","volume":"139","author":"Phillips JH","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_1_38_2","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.4049\/jimmunol.140.10.3660","article-title":"Induction of natural killer cell effectors from human thymus with recombinant IL\u20102","volume":"140","author":"Michon JM","year":"1988","journal-title":"J Immunol"},{"key":"e_1_2_1_39_2","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.4049\/jimmunol.140.5.1685","article-title":"CD3\u2010negative lymphokin\u2010activated cytotoxic cells express the CD3\u03f5 gene","volume":"140","author":"Biossoni R","year":"1988","journal-title":"J Immunol"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.145.5.1411"},{"key":"e_1_2_1_41_2","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.4049\/jimmunol.134.6.3731","article-title":"Origin and differentiation of natural killer cells: I. Characteristics of a transplantable NK cell precursor","volume":"134","author":"Hackett J","year":"1985","journal-title":"J Immunol"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(89)90151-2"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890701)64:1<63::AID-CNCR2820640111>3.0.CO;2-#"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830330107"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900515)65:10<2243::AID-CNCR2820651014>3.0.CO;2-D"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113352"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90236-4"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19871215)60:12<2971::AID-CNCR2820601220>3.0.CO;2-O"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/94.3.334"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198709000-00005"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830400211","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830400211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T13:25:44Z","timestamp":1698067544000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830400211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,6]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992,6]]}},"alternative-id":["10.1002\/ajh.2830400211"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830400211","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,6]]}}}