{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T12:08:43Z","timestamp":1759579723662},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":5123,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1992,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The CALGB prospectively studied 140 adult acute lymphoblastic leukemia (ALL) patients for cytogenetic abnormalities. Seven (5%) patients with adequate cytogenetic preparations had t(8;14)(q24;q32) or t(8;22)(q24;q11). Patients were compared with non\u20108q24 patients for clinical and laboratory characteristics, response to therapy, and survival. The median age of patients with translocations involving 8q24 (71% males) was 40 years. Forty\u2010three percent had lymphadenopathy, 29% splenomegaly, and 29% hepatomegaly. None exhibited central nervous system (CNS), skin, or gum involvement. These features did not differ significantly from non\u20108q24 ALLs. Patients with 8q24 translocations had higher hemoglobins (11.5 vs. 9.8 g\/dl; <jats:italic>P<\/jats:italic> = 0.04) and lower percentage of blasts in the peripheral blood (8.5% vs. 69%; <jats:italic>P<\/jats:italic> = 0.007). Although all seven were finally categorized as ALL\u2010L3, a marked variation in the proportion of typical L3 blasts was observed that initially resulted in the diagnoses of ALL\u2010L2 in three cases and prolymphocytic leukemia in one. In five of five patients, the blasts typed as B cells (Slg+ and CD19+). Complete remission rates for patients with 8q24 translocations were 43%, whereas they were 68% for non\u20108q24 ALLS (<jats:italic>P<\/jats:italic> = 0.22). Furthermore, patients with 8q24 abnormalities exhibited significantly shorter survival (4.8 vs. 18.4 mo; <jats:italic>P<\/jats:italic> &lt; 0.001). We conclude that ALL with translocations of 8q24 in adults shows a mature B\u2010cell immunophenotype (Slg+), poor prognosis and morphology ranging from classical ALL\u2010L3 to ALL with a subpopulation of L3 cells. Thus, the diagnosis of ALL\u2010L3 should be made when blastic cells possess a mature B\u2010cell immunophenotype (SIg+) and an 8q24 translocation, even though the number of L3 cells is low. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830400306","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:02:05Z","timestamp":1172062925000},"page":"183-191","source":"Crossref","is-referenced-by-count":5,"title":["Morphologic characteristics of acute lymphoblastic leukemia (ALL) with abnormalities of chromosome 8, band q24"],"prefix":"10.1002","volume":"40","author":[{"given":"F. 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