{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T09:41:01Z","timestamp":1698140461424},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":5123,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1992,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aplastic anemia includes a group of disorders characterized by peripheral blood pancytopenia and marrow hypocellularity. The current report describes a patient who is an apparent constitutional mosaic and presented with marrow aplasia. Using cytogenetic analysis of bone marrow, skin, and peripheral T lymphocytes, we demonstrate the clonal nature of this patient's aplastic marrow, and, in addition, identify clonal evolution. The patient was treated with antithymocyte globulin (ATG) and achieved a complete remission, with disappearance of an abnormal evolved clone. This case illustrates that clonal cytogenetic abnormalities do not preclude a response to ATG and that aplastic anemia may be a nonmalignant clonal disorder with clonal evolution. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830400314","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:02:05Z","timestamp":1172062925000},"page":"229-231","source":"Crossref","is-referenced-by-count":4,"title":["Clonal remission in aplastic anemia after treatment with antithymocyte globulin"],"prefix":"10.1002","volume":"40","author":[{"given":"Theodore","family":"Wun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry P.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198203183061105"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(18)30478-7"},{"key":"e_1_2_1_4_2","first-page":"1134","article-title":"Clonal cytogenetic abnormalities in patients with otherwise typical aplastic anemia","volume":"15","author":"Appelbaum FR","year":"1987","journal-title":"Exp Hematol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1988.tb02434.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1988.tb02382.x"},{"key":"e_1_2_1_7_2","first-page":"1425","article-title":"Aplastic leukaemia syndrome","volume":"1","year":"1989","journal-title":"Lancet"},{"key":"e_1_2_1_8_2","first-page":"700","article-title":"Genetics in colon cancer","volume":"154","author":"Ahnen DJ","year":"1991","journal-title":"West J Med"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1182\/blood.V77.7.1415.1415","article-title":"Clonal remissions in acute nonlymphocytic leukemia: evidence for a multi\u2010step pathogenesis of the malignancy","volume":"77","author":"Fialkow PJ","year":"1991","journal-title":"Blood"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198301203080301"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1182\/blood.V70.4.1046.1046","article-title":"Survival after antilymphocyte globulin therapy for aplastic anemia depends on disease severity","volume":"70","author":"Marsh JCW","year":"1987","journal-title":"Blood"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199105093241901"},{"key":"e_1_2_1_13_2","first-page":"229a","article-title":"Antithymocyte globulin for hypoplastic myelodysplastic syndrome","volume":"72","author":"Sulecki M","year":"1988","journal-title":"Blood"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1988.tb04194.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.14.4823"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1600-0609.1990.tb00387.x","article-title":"Anti\u2010lymphocyte immunoglobulins stimulate peripheral blood lymphocytes to proliferate and release lymphokines","volume":"42","author":"Taniguchi Y","year":"1990","journal-title":"Eur J Haematol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1182\/blood.V78.1.163.163","article-title":"In vitro production of granulocyte\u2010macrophage colony stimulating factor in aplastic anemia; possible mechanisms of action of anti\u2010thymocyte globulin","volume":"78","author":"Nimer SD","year":"1991","journal-title":"Blood"},{"key":"e_1_2_1_18_2","first-page":"146","volume-title":"Hematology\u2014Basic Principles and Practice","author":"Young NS","year":"1991"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830400314","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830400314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T20:51:15Z","timestamp":1698094275000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830400314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,7]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,7]]}},"alternative-id":["10.1002\/ajh.2830400314"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830400314","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,7]]}}}