{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:41:54Z","timestamp":1761100914657},"reference-count":5,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":5123,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1992,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lymphocyte predominance Hodgkin's disease (LPHD) can be histogically subdivided into a nodular and diffuse variety. The two subtypes differ in immunophenotypic characteristics but have a similar long\u2010term clinical outcome. Nodular LPHD has immunophenotypic and histological characteristics suggestive of a B\u2010cell derived neoplastic process. Nodular LPHD is associated with an increased risk of secondary large cell lymphoma (LCL). Gene rearrangement studies in some of these cases have revealed a B\u2010cell clonal process, further supporting the association between nodular LPHD and the B\u2010cell system. In addition, it has been suggested that the apparent secondary LCL, at least in some cases, may represent a histologic progression of nodular LPHD. We report a unique case of T\u2010cell lymphoma, confirmed by T\u2010cell receptor gene rearrangement studies, which developed in the setting of nodular LPHD. Our observation demonstrates that the association of nodular LPHD and LCL is complex and that LCL developing in the context of nodular LPHD may be an independent secondary process sometimes involving T\u2010cell lymphomas. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830400315","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:02:05Z","timestamp":1172062925000},"page":"232-233","source":"Crossref","is-referenced-by-count":8,"title":["Secondary T\u2010cell lymphoma in the setting of nodular lymphocyte predominance Hodgkin's disease"],"prefix":"10.1002","volume":"40","author":[{"given":"A.","family":"Tefferi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"Wiltsie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Kurtin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1200\/JCO.1990.8.12.1959","article-title":"Clinical correlates of distinct immunophenotypic and histologic subcategories of lymphocyte predominance Hodgkin's disease","volume":"8","author":"Tefferi A","year":"1990","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198404000-00002"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198801283180404"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830615)51:12<2293::AID-CNCR2820511221>3.0.CO;2-X"},{"key":"e_1_2_1_6_2","first-page":"599","article-title":"Lymphocyte predominant Hodgkin's disease nodular subtype with coexistent \u201clarge cell lymphoma\u201d","volume":"12","author":"Sundeen JT","year":"1988","journal-title":"Histological progression or composite malignancy? Am J Surg Pathol"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830400315","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830400315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T20:50:06Z","timestamp":1698094206000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830400315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,7]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,7]]}},"alternative-id":["10.1002\/ajh.2830400315"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830400315","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,7]]}}}