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CD72 expression in normal and malignant tissues is different from expression of all other previously described human B\u2010cell antigens. In peripheral blood and bone marrow, the antigen appears to be present on all B lymphocytes, with the exception of plasma cells. In tissue, immunohistochemical staining revealed positivity for all known B\u2010cell compartments; however, pulpa macrophages of the spleen and von Kupffer cells exhibited distinct positivity for CD72 also. Among 83 malignant non\u2010Hodgkin's lymphomas examined by immunohistochemistry (alkaline phosphatase anti\u2010alkaline phosphatase technique), all 54 B\u2010cell lymphomas, including precursor B\u2010cell lymphomas, Burkitt's lymphomas, germinal center lymphomas, chronic lymphocytic leukemias, and hairy cell leukemias, were CD72 positive, but no T\u2010cell lymphomas were. Flow cytometry study of more than 80 mainly acute leukemias (52 B\u2010cell leukemias) showed reactivity with S\u2010HCL 2 mAb over the full range of B\u2010cell differentiation. In particular, very early B cells in cytoplasmic Ig (clg)\u2010negative, CD19\u2010positive prepre\u2010B\u2010cell leukemias and hybrid leukemias (mixed myeloid and B\u2010cell type) were consistently positive for CD72 on the cell surface. Therefore, CD72 may become an important marker for progenitor B\u2010cell leukemias. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830410303","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T12:55:40Z","timestamp":1172062540000},"page":"151-158","source":"Crossref","is-referenced-by-count":22,"title":["Human Lyb\u20102 homolog CD72 is a marker for progenitor B\u2010cell leukemias"],"prefix":"10.1002","volume":"41","author":[{"given":"Roland","family":"Schwarting","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Castello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Moldenhauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pezzutto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"D\u00f6rken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Llka Von","family":"Hoegen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane R.","family":"Parnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf\u2010Dieter","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1182\/blood.V65.4.974.974","article-title":"The monoclonal antibodies alpha S\u2010HCL 1 (alpha Leu\u201014) and alpha S\u2010HCL 3 (alpha Leu\u2010M5) allow the diagnosis of hairy cell leukemia","volume":"65","author":"Schwarting R","year":"1985","journal-title":"Blood"},{"key":"e_1_2_1_3_2","first-page":"302","volume-title":"Leucocyte Typing III. 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