{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T06:32:01Z","timestamp":1785825121952,"version":"3.56.0"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4970,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1992,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a case of a 32\u2010year\u2010old male, an asymptomatic carrier of human T\u2010cell leukemia virus type 1 (HTLV\u20101), who underwent a renal transplantation and developed adult T\u2010cell leukemia (ATL) during the course of posttransplant immunosuppressive treatment. He was treated with combination chemotherapies consisting of cyclophosphamide, vincristine, doxorubicin, prednisolone, cisplatin, cytosine arabinoside, etoposide, and methyl\u2010prednisolone, without any improvement. Bestrabucil (KM2210), a conjugate of chlorambucil and estradiol, was administered as an alternative therapy; this therapy successfully suppressed his leukemic cell growth, and partial remission was achieved. Posttransplant immunosuppressive therapy with prednisolone, mizoribine, and cyclosporin A might have been the predominant cause of the transition from an asymptomatic HTLV\u20101 infection to overt ATL. A careful approach is required with HTLV\u20101 asymptomatic carriers who need organ transplantation followed by immunosuppressive treatment. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830410414","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T12:54:49Z","timestamp":1172062489000},"page":"292-294","source":"Crossref","is-referenced-by-count":39,"title":["Adult T\u2010cell leukemia developing during immunosuppressive treatment in a renal transplant recipient"],"prefix":"10.1002","volume":"41","author":[{"given":"Hisashi","family":"Tsurumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenzaburo","family":"Tani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihisa","family":"Tsuruta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risa","family":"Shirato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadahiro","family":"Matsudaira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arinobu","family":"Tojo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikashi","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisanori","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiya","family":"Ozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigetaka","family":"Asano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V50.3.481.481"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910330602"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90994-2"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910815)68:4<695::AID-CNCR2820680405>3.0.CO;2-K"},{"key":"e_1_2_1_6_2","unstructured":"MatsudairaT KodoH OkamotoS TaniK TojoA OzawaK AsanoK AsanoS:Alloantigen\u2010specific immunosuppressive activity of estra\u2010diol\u2010chlorambucil conjugate (KM2210) and its beneficial effect on allogeneic bone marrow transplantation in mice. Transplantation (inpress)."},{"key":"e_1_2_1_7_2","first-page":"349","article-title":"Anti\u2010ATLA antibodies in renal transplant recipients and donor","volume":"23","author":"Kokado Y","year":"1988","journal-title":"Jpn J Transpl"},{"key":"e_1_2_1_8_2","first-page":"695","article-title":"HTLV\u20101 T cell lymphoma in a cyclosporin\u2010treated renal transplant patient","volume":"48","author":"Zanke BW","year":"1989","journal-title":"Transplantation"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.152.3718.78"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.149.3691.1511"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1093\/jnci\/52.6.1881","article-title":"Enhanced production of mouse mammary tumor virus in dexamethasone\u2010treated, 5\u2010iododeoxyuridine\u2010stimulated mammary tumor cell cultures","volume":"52","author":"Fine DL","year":"1974","journal-title":"J Natl Cancer Inst"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830410414","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830410414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T20:37:30Z","timestamp":1698093450000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830410414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,12]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,12]]}},"alternative-id":["10.1002\/ajh.2830410414"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830410414","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,12]]}}}